【摘要】 目的 了解高校男大学生对人乳头瘤病毒(Human papilloma virus, HPV)疫苗的选择偏好和支付意愿(Willingness to pay, WTP)。方法 采用分层整群抽样方法在北京市某高校选择4个年级28个班级的男大学生开展离散选择实验(Discrete choice experiment, DCE);DCE包括HPV疫苗预约接种方式、严重不良反应风险、可预防疾病覆盖水平、保护时间、接种剂次、费用和接种点7项属性及其水平组合的8个选择集。应用混合Logit模型计算HPV疫苗各疫苗属性选择偏好的偏回归系数β值和WTP值。结果 共纳入研究对象228例。混合Logit模型分析显示，研究对象选择HPV疫苗互联网预约(与现场预约相比)接种、校内(与校外相比)接种点、低水平(与高水平相比)严重不良反应风险、高覆盖(与低覆盖相比)可预防疾病、保护时间为45年(与15年相比)、接种1剂次(与3剂次相比)等属性水平的β值(95%CI)分别为0.775(0.523～1.027)、0.066(-0.221～0.352)、0.334(0.127～0.541)、0.917(0.679～1.155)、0.537(0.285～0.789)、0.465(0.167～0.763),WTP值(95%CI)分别为557.21(339.07～775.35)元、47.14(-157.95～252.22)元、240.31(71.03～409.58)元、659.22(461.47～856.98)元、386.09(201.58～570.59)元、334.30(135.30～533.30)元；每剂次疫苗费用选择偏好的β值(95%CI)为-0.001(-0.002～-0.001)。结论 男大学生对HPV疫苗的选择偏好受疫苗预约接种方式、严重不良反应风险、可预防疾病、保护时间、接种剂次和费用的影响；对互联网预约、高覆盖可预防疾病、提高长期保护、低严重不良反应风险和接种1剂次的疫苗具有较高的支付意愿。更多还原

【Abstract】 Objective To explore preferences and willingness to pay(WTP) for human papillomavirus(HPV) vaccine among male undergraduates.Methods We selected male undergraduates from 28 classes across 4 academic years in a university of Beijing using a stratified cluster sampling method and conducted a discrete choice experiment(DCE). The DCE included eight choice sets composed of seven vaccine attributes(appointment making method, risk of severe adverse reactions, diseases prevented, duration of protection, vaccination regimen, vaccine cost, and vaccination site) with varying levels. We used a mixed logit model to estimate preference coefficients(β) and corresponding WTP values of attribute levels.Results A total of 228 participants were enrolled. The mixed logit model showed that participants preferred HPV vaccines given through Internet-made(vs on-site) appointments, at on-campus(vs off-campus) vaccination sites, with low-risk(vs high-risk) severe adverse reactions, that have high coverage(vs low coverage) against preventable diseases, with 45-years(vs 15-years) of protection, and given in a one-dose(vs three-dose) regimen, with β values(95% CI) of 0.775(0.523 to 1.027), 0.066(-0.221 to 0.352), 0.334(0.127 to 0.541), 0.917(0.679 to 1.155), 0.537(0.285 to 0.789), and 0.465(0.167 to 0.763), respectively; and corresponding WTP values(95% CI) of 557.21(339.07 to 775.35), 47.14(-157.95 to 252.22), 240.31(71.03 to 409.58), 659.22(461.47 to 856.98), 386.09(201.58 to 570.59), and 334.30(135.30 to 533.30) yuan; the β value(95% CI) of preference for vaccine cost per dose was-0.001(-0.002 to-0.001).Conclusions Preferences for HPV vaccination among male undergraduates were influenced by appointment method, risk of severe adverse reactions, coverage against preventable diseases, duration of protection, vaccination regimen, and vaccine costs, with highest WTP for Internet-based vaccination appointments, high-coverage against preventable diseases, long duration of protection, low-risk severe adverse reactions, and a one-dose regimen.更多还原