【摘要】 目的 分析胆胃郁热型原发性胆汁反流性胃炎(PBRG)患者采用黄芩加半夏生姜汤合小陷胸汤进行治疗的临床效果。方法 选取大连理工大学附属中心医院在2023年1月至2024年12月60例胆胃郁热型PBRG患者，按照随机数字表法将其分为两组，每组30例，对照组患者采用西药治疗(雷贝拉唑钠肠溶片+多潘立酮片)，试验组在对照组治疗基础上加用黄芩加半夏生姜汤合小陷胸汤，就两组胃功能指标[胃泌素(GAS)与胃动素(MTL)]；炎症反应指标[白细胞介素-6(IL-6)与肿瘤坏死因子α(TNF-α)]；中医证候积分；临床疗效对比。结果 与对照组进行对比，试验组治疗8周时有着更高的GAS、MTL水平(P<0.05)，更低的IL-6、TNF-α水平与中医证候积分(P<0.05)。相比对照组(73.33%)，试验组(96.67%)有着更高的总有效率(P<0.05)。结论 针对PBRG(胆胃郁热型)患者，通过给予黄芩加半夏生姜汤合小陷胸汤治疗，效果较好，能改善其症状与胃功能，降低炎症反应。更多还原

【Abstract】 Objective To analyze the clinical efficacy of Huangqin and Banxia Shengjiang decoction combined with Xiaoxianxiong decoction in the treatment of patients with primary biliary reflux gastritis(PBRG) of gallbladder-stomach stagnant heat type.Methods Sixty patients with PBRG of the type of bile-stomach heat stagnation in Dalian University of Technology Affiliated Central Hospital from January 2023 to December 2024 were selected and randomly divided into two groups according to the random number table method,with 30 cases in each group.The control group was treated with western medicine(rabeprazole sodium enteric-coated tablets+domperidone tablets),while the trial group was treated with Huangqin and Banxia Shengjiang decoction combined with Xiaoxianxiong decoction on the basis of the control group.The following indicators were compared between the two groups:gastric function indicators [gastrin(GAS) and motilin(MTL)],inflammatory response indicators [interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α)],syndrome score,and clinical efficacy.Results Compared with the control group,the trial group had higher GAS and MTL levels(P<0.05),lower IL-6 and TNF-α levels and TCM syndrome scores(P<0.05) at 8 weeks of treatment.Compared with the control group(73.33%),the trial group(96.67%) had a higher total effective rate(P<0.05).Conclusions For patients with PBRG(gallbladder and stomach heat stagnation type),the treatment with Huangqin and Banxia Shengjiang decoction combined with Xiaoxianxiong decoction combined with Xiaoxianxiong decoction has achieved good results,significantly improving their symptoms and gastric function,and reducing inflammatory responses.更多还原