【摘要】 目的 探讨自体血回输（IOCS）在神经外科手术中的应用效果及对凝血功能的影响。方法 选择2021年1月至2025年9月芜湖市第一人民医院收治的65例神经外科手术中大出血患者作为研究对象，按数字表法随机分为观察组（n=33例）和对照组（n=32），对照组采用传统同种异体血输注，观察组采用IOCS方式。比较两组术后并发症发生率，及术前及术后12 h内凝血功能、血红蛋白（HB）、红细胞分布宽度（RDW）、总蛋白（TP）、白蛋白（ALB）等差异。结果 术后两组凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）均延长，HB、TP、ALB均降低，但观察组PT、APTT延长程度及HB、TP、ALB降低幅度均小于对照组；同时，观察组凝血酶时间（TT）更短、纤维蛋白原（FIB）较对照组更高（P<0.05）。两组术后并发症比较，差异无统计学意义（P>0.05）。结论 IOCS用于神经外科手术疗效确切，可减轻术后凝血功能、血液营养成分的异常波动。更多还原

【Abstract】 Objective To explore the application effect of autologous blood reinfusion(IOCS) in neurosurgery and its influence on coagulation function. Methods A total of 65 patients who experienced massive hemorrhage during neurosurgery and were admitted to Wuhu First People’s Hospital from January 2021 to September 2025 were selected as research subjects. They were randomly divided into two groups: the observation group(n=33 cases) and the control group(n=32 cases) using the digital table method. The control group received traditional allogeneic blood transfusion, while the observation group received treatment with IOCS. The incidence of postoperative complications was compared between the two groups, as well as differences in coagulation function, hemoglobin(HB), red blood cell distribution width(RDW), total protein(TP), albumin(ALB) were analyzed before and within 12 hours after the operation. Results After the operation, both groups showed prolonged prothrombin time(PT) and activated partial thromboplastin time(APTT), as well as decreased levels of hemoglobin(HB), TP, and ALB. However, the observation group had smaller prolongation degrees of PT and APTT, as well as a less extent of decrease in HB, TP, and ALB compared to the control group. Meanwhile, the observation group had a shorter TT and higher fibrinogen(FIB) levels(P<0.05). There was no statistically significant difference in postoperative complications between the two groups(P>0.05). Conclusion IOCS has definite therapeutic effects in neurosurgical operations and can alleviate abnormal fluctuations in postoperative coagulation function and blood nutritional components.更多还原