【摘要】 目的:系统梳理生姜炮制方法的历史沿革，并探究其治疗阿尔茨海默病、帕金森病、多发性硬化症等神经退行性疾病的潜在作用机制。方法:通过文献考证与可视化分析，梳理自东汉至近代生姜炮制技术演变；采用网络药理学方法，筛选生姜活性成分、预测其靶点与通路，并构建“成分-靶点-通路”网络进行分析。在此基础上，对筛选出的主要活性成分与核心靶点进行分子对接验证。结果:历史分析显示，生姜炮制方法历经由简入繁、再趋规范的演变过程。网络药理学表明，生姜治疗阿尔茨海默病与帕金森病主要涉及神经活性配体-受体相互作用通路；治疗多发性硬化症则与脂质与动脉粥样硬化通路相关。分子对接结果表明，核心活性成分与关键靶点能够形成稳定的结合构象。结论:该研究厘清了生姜炮制技术的历史脉络，并揭示了其通过多通路、多靶点治疗不同神经退行性疾病的潜在机制差异，为阐释炮制演变规律及其现代临床应用提供依据。更多还原

【Abstract】 Objective:To systematically reconstruct the historical evolution of ginger processing(Paozhi) techniques and to elucidate the potential mechanisms underlying its therapeutic effects on neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.Methods:Through historical textual research and visualization analysis, the evolution of ginger processing techniques from the Eastern Han Dynasty to modern times was systematically examined.Network pharmacology was applied to identify the active components of ginger and their putative targets, followed by the construction of a “component-target-pathway” network.Molecular docking analysis was further conducted to evaluate the binding affinity between core active compounds and key targets.Results:Historical analysis demonstrated that ginger processing techniques evolved from simple practices to increasingly complex methods, followed by gradual standardization.Network pharmacology analysis revealed that the therapeutic effects of ginger on Alzheimer’s disease and Parkinson’s disease are primarily mediated through the neuroactive ligand-receptor interaction pathway, whereas its effects on multiple sclerosis are mainly associated with the lipid and atherosclerosis pathway.The molecular docking results indicated that the core active ingredient is capable of forming a stable binding conformation with the key target.Conclusion:This study clarifies the historical trajectory of ginger processing techniques and reveals disease-specific differences in its potential therapeutic mechanisms mediated by multiple targets and pathways.These findings provide a theoretical basis for understanding the historical evolution of ginger processing methods and their relevance into modern clinical applications.更多还原