【摘要】 子宫粘连（intrauterine adhesion,IUA）是当代女性不孕、流产、反复移植失败的主要原因，其主要表现为子宫内膜纤维化。建立合适的动物模型对于子宫粘连机制的研究至关重要。在本文中，我们总结了不同的动物子宫粘连建模的发展过程及方法，包括采用机械损伤、95%乙醇注射、双重损伤等方法建立IUA模型，为研究人员提供参考。同时还回顾了当前应用IUA动物模型研究子宫粘连治疗方案的研究进展，尽管目前热门的干细胞疗法、富血小板血浆、生物工程技术不断发展，对IUA的治疗方案主要是宫腔镜粘连松解术后预防再粘连，但治疗后再粘连率仍然居高不下，且存在一定的副作用。新兴治疗方案如透明质酸、羊膜移植等现无明确的治疗效果，未来仍需探索IUA的发病机制，以找寻治疗IUA的最佳方案。更多还原

【Abstract】 Intrauterine adhesion(IUA) is the main cause of modern female infertility, which is mainly manifested by endometrial fibrosis. It is very important to establish a suitable animal model for the study of the mechanism of uterine adhesion. In this paper, we summarized the development process and methods of different animal uterine adhesion modeling, including the establishment of IUA models using mechanical injury, 95% ethanol injection,double injury, etc., to provide reference for researchers. At the same time, the current research progress on the treatment of uterine adhesions using IUA animal models is reviewed. Although the current popular stem cell therapy, platelet-rich plasma, and bioengineering technology continue to develop, the treatment of IUA has not been unified. In the future, it is still necessary to explore the pathogenesis of IUA to find the best treatment plan for IUA.更多还原