【摘要】 目的 探究腹腔镜下结直肠癌根治术联合洛铂灌洗化疗的有效性与安全性。方法 选取2024年1月至2025年3月于百色市人民医院胃肠外科办理住院的90例结直肠癌患者作为研究对象，根据术中是否接受洛铂灌洗化疗将其分为对照组（45例，腹腔镜下结直肠癌根治术+常规生理盐水冲洗）和研究组（45例，腹腔镜下结直肠癌根治术+洛铂灌洗化疗）。比较两组的实验室指标、术后恢复情况及并发症发生情况。结果 术后2、15 d，两组的白细胞计数、血小板计数、天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、血肌酐（Scr）、血尿素氮（BUN）水平无显著差异（P>0.05）；术前，两组的癌胚抗原（CEA）、糖类抗原199(CA199)、糖类抗原125(CA125)水平无显著差异（P>0.05）；术后，两组的CEA、CA199、CA125水平均降低，且研究组低于对照组（P<0.05）。研究组的引流管留置时间略长于对照组，住院时间略短于对照组，但差异无统计学意义（P>0.05）。两组的出血、吻合口瘘、切口愈合不良、腹盆腔脓肿、肠梗阻、肺部感染发生率无显著差异（P>0.05）。结论 腹腔镜下结直肠癌根治术联合洛铂灌洗化疗能有效降低肿瘤标志物水平，且安全性良好。更多还原

【Abstract】 Objective To explore the efficacy and safety of laparoscopic radical resection of colorectal cancer combined with lobaplatin lavage chemotherapy. Methods A total of 90 patients with colorectal cancer who were hospitalized in the gastrointestinal surgery department of Baise People’s Hospital from January2024 to March 2025 were selected as the research objects. According to whether the patients received lobaplatin lavage chemotherapy during the operation, they were divided into control group(45 cases, laparoscopic radical resection of colorectal cancer + conventional saline irrigation) and study group(45 cases, laparoscopic radical resection of colorectal cancer + lobaplatin lavage chemotherapy). The laboratory indexes, postoperative recovery and complications were compared between the two groups. Results There were no significant differences in white blood cell count, platelet count, aspartate aminotransferase(AST), alanine aminotransferase(ALT),serum creatinine(Scr) and blood urea nitrogen(BUN) levels between the two groups at 2 and 15 d after operation(P >0.05); before operation, there were no significant differences in the levels of carcinoembryonic antigen(CEA), carbohydrate antigen 199(CA199) and carbohydrate antigen 125(CA125) between the two groups(P >0.05); after operation, the levels of CEA, CA199 and CA125 in the two groups decreased, and those in the study group were lower than the control group(P<0.05). The drainage tube indwelling time of the study group was slightly longer than that of the control group, the hospitalization time was slightly shorter than that of the control group, but the differences were not statistically significant(P>0.05). There were no significant differences in the incidences of bleeding, anastomotic leakage, poor wound healing, abdominal and pelvic abscess, intestinal obstruction and pulmonary infection between the two groups(P>0.05). Conclusion Laparoscopic radical resection of colorectal cancer combined with lobaplatin lavage chemotherapy can effectively reduce the levels of tumor markers, and has good safety.更多还原