【摘要】 溃疡性结肠炎（UC）是一种发病机制尚未完全明确的慢性非特异性肠道炎症性疾病，病程迁延、反复发作，严重影响患者的生活质量和身心健康，患者患病期间常并发焦虑、抑郁等心理障碍。近年研究表明，心理应激可通过肠道-脑轴加剧肠道局部炎症反应；而认知行为疗法（CBT）、正念干预（MBI）等心理干预手段，可通过调控神经内分泌-免疫通路发挥抗炎效应。本文系统综述心理干预对UC患者C反应蛋白（CRP）、粪便钙卫蛋白（FC）、细胞因子等炎症生物标志物的影响，深入探讨其潜在作用机制及临床应用价值，以期为优化UC整合治疗策略提供理论依据。更多还原

【Abstract】 Ulcerative colitis(UC) is a chronic non-specific inflammatory bowel disease with incompletely clarified pathogenesis, characterized by a protracted course and frequent relapses, which severely impacts on patients’ quality of life and psychophysical health, and patients frequently suffer from psychological disorders such as anxiety and depression during the disease course. Recent studies have demonstrated that psychological stress can exacerbate local intestinal inflammatory responses via the gut-brain axis; while psychological interventions such as cognitive behavioral therapy(CBT) and mindfulness-based intervention(MBI) may exert anti-inflammatory effects by regulating the neuroendocrine-immune pathway. This paper systematically reviews the effects of psychological interventions on inflammatory biomarkers such as Creactive protein(CRP), fecal calprotectin(FC) and cytokines in patients with UC, and deeply explores their potential mechanisms of action and clinical application value, so as to provide a theoretical basis for optimizing the integrated treatment strategy of UC.更多还原