【摘要】 电化学C—H键活化以其优异的原子经济性、丰富的反应位点、环境友好性以及无需底物预官能团化等优势备受关注.C—N/C—O键广泛存在于许多天然产物和药物分子中,是生命体系中重要的结构,因此其高效构建方法的研究具有重要意义.近年来,随着绿色化学理念的深入,无金属参与的电化学C—H键活化构建CN/C—O键因其避免金属残留、成本低廉且环境友好等优势,正日益成为研究热点.该领域已开发出多种通过电化学C—H键活化构建C—N/C—O键策略.系统总结了近五年来无金属电化学C—H键活化构建C—N/C—O键的重要进展,涵盖直接C—N/C—O键的构建及非金属介导的C—N/C—O键的构建,并重点阐述了相关反应机理.更多还原

【Abstract】 Electrochemical C—H bond activation has garnered significant attention due to its superior atom economy,abundant reaction sites,environmental friendliness,and the absence of substrate pre-functionalization requirements.C—N/C—O bonds,which are widely present in numerous natural products and pharmaceutical molecules,serve as crucial structural motifs in biological systems,making the development of efficient methodologies for their construction highly consequential.In recent years,with the growing emphasis on green chemistry principles,metal-free electrochemical C—H bond activation for C—N/C—O bond formation has emerged as a prominent research focus,owing to its advantages in avoiding metal residues,cost-effectiveness,and environmental compatibility.This field has witnessed the development of diverse strategies for constructing C—N/C—O bonds via electrochemical C—H activation.The key advancements in metal-free electrochemical C—H activation for C一N/C一O bond formation over the past five years are systematically reviewed,encompassing both direct C—N/C—O bond construction and non-metal-mediated approaches,with particular emphasis on elucidating the underlying reaction mechanisms.更多还原