【摘要】 目的：探讨¹⁸F-氟代脱氧葡萄糖正电子发射计算机断层成像(¹⁸F-FDG PET/CT)诊断非小细胞肺癌（NSCLC）患者纵隔淋巴结转移的价值。方法：连续性纳入2023年1月-2024年12月徐州市第一人民医院收治的90例NSCLC患者，均行CT平扫与¹⁸F-FDG PET/CT检查。CT以淋巴结最短径>1 cm为转移判定标准，¹⁸F-FDG PET/CT以最大标准化摄取值（SUVmax）>2.5为转移阳性标准，图像由2名资深核医学医师双盲分析。以手术病理结果为金标准，对比两种检查的诊断效能。结果：90例患者中，病理确诊33例纵隔淋巴结转移（占比36.67%）。¹⁸F-FDG PET/CT的敏感度（84.85%）、特异度（87.72%）、准确率（86.67%）均高于CT（60.61%、64.91%、63.33%），差异均有统计学意义（P<0.05）。结论：¹⁸F-FDG PET/CT诊断NSCLC患者纵隔淋巴结转移的效能优于CT，可为患者术前转移评估、临床分期及治疗方案制定提供可靠参考。更多还原

【Abstract】 Objective: To explore the diagnostic value of¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography(¹⁸F-FDG PET/CT) for mediastinal lymph node metastasis in patients with non-small cell lung cancer（NSCLC）. Methods: A total of 90 NSCLC patients admitted to Xuzhou NO.1 People’s Hospital from January 2023 to December 2024 were consecutively enrolled, all of whom underwent plain CT scan and¹⁸F-FDG PET/CT examination. CT used lymph node short diameter >1 cm as the criterion for metastasis, while¹⁸F-FDG PET/CT took maximum standardized uptake value（SUVmax） >2.5 as the positive sign for metastasis. Images were analyzed by 2 senior nuclear medicine physicians with double-blind method. Taking surgical pathological results as the gold standard, the diagnostic efficacy of the two examinations was compared. Results: Among 90 patients, 33 cases were pathologically confirmed with mediastinal lymph node metastasis（accounting for 36.67%）. The sensitivity（84.85%）,specificity（87.72%） and accuracy（86.67%） of¹⁸F-FDG PET/CT were higher than those of CT（60.61%,64.91%, 63.33%）, and all differences were statistically significant（P<0.05）. Conclusion: The diagnostic efficacy of¹⁸F-FDG PET/CT for mediastinal lymph node metastasis in NSCLC patients is superior to that of CT, which can provide reliable reference for preoperative metastasis evaluation, clinical staging and treatment plan formulation of patients.更多还原