【摘要】 目的 分析血清系统免疫炎症指数（SII）、甘油三酯葡萄糖指数（TyG）水平与急性冠脉综合征（ACS）患者行急诊经皮冠状动脉介入治疗（PCI）术后发生主要不良心血管事件（MACE）的关联性。方法 选取新疆医科大学第一附属医院2013年6月至2023年6月行急诊PCI术的ACS患者918例，收集患者临床信息及入院检查结果，根据血常规检查计算SII，根据生化检查计算TyG。对患者进行随访，根据是否发生主要不良心血管事件，将患者分为MACE组和非MACE组，采用单因素Logistic回归分析及多因素Logistic回归分析急性冠脉综合征患者急诊PCI术后发生主要不良心血管事件的相关因素，绘制受试者工作特征（ROC）曲线，来评估血清SII、TyG水平对该人群术后MACE的预测价值。结果 918例ACS患者急诊PCI术后1年MACE发生率为22.77%(209/918)。非MACE组SII、TyG水平低于MACE组[SII:851.23(576.39,1305.27) vs 1409.42(911.48,1955.90);TyG:8.82(8.44,9.23) vs 9.37(8.85,9.83)]，差异有统计学意义（P<0.05）。年龄增加及升高的SII、TyG水平是ACS患者行急诊PCI术后发生MACE的独立影响因素（P<0.05）。血清SII、TyG水平单独预测ACS患者行急诊PCI术后发生MACE事件的ROC曲线的曲线下面积（AUC）分别为0.691、0.699，两指标联合预测ACS患者行急诊PCI术后发生MACE事件的ROC曲线的AUC为0.737，高于两指标单独检测。结论 血清SII、TyG水平升高与急性冠脉综合征患者行急诊经皮冠状动脉介入治疗发生术后主要不良心血管事件风险增加相关，二者联合检测对术后MACE具有较高的预测价值。更多还原

【Abstract】 Objective To analyze the relationships of serum systemic immune-inflammation index(SII) and triglyceride-glucose index(TyG) levels with the occurrence of major adverse cardiovascular events(MACE) in patients with acute coronary syndrome(ACS) undergoing emergency percutaneous coronary intervention(PCI). Methods A total of 918 ACS patients who underwent emergency PCI at The First Affiliated Hospital of Xinjiang Medical University between June 2013 and June 2023 were selected. Clinical information and admission laboratory data were collected. SII was calculated based on routine blood tests, and TyG was calculated based on biochemical tests. Patients were followed up and divided into a MACE group and a non-MACE group based on the occurrence of MACE. Univariable and multivariable logistic regression analyses were performed to identify factors associated with MACE after emergency PCI in ACS patients. Receiver operating characteristic curves were constructed to evaluate the predictive value of serum SII and TyG levels for postoperative MACE in this population. Results The incidence of MACE at 1 year after emergency PCI in the 918 ACS patients was 22.77%(209/918). SII and TyG levels in the non-MACE group were lower than those in the MACE group [SII: 851.23(576.39, 1305.27) vs 1409.42(911.48, 1955.90); TyG: 8.82(8.44, 9.23) vs 9.37(8.85, 9.83)], with statistically significant differences(P<0.05). Advanced age and elevated SII and TyG levels were identified as independent risk factors for MACE after emergency PCI in ACS patients(P<0.05). The areas under the receiver operating characteristic curves for predicting MACE using serum SII and TyG alone were 0.691 and 0.699, respectively. The area under the curve for the prediction of MACE using both SII and TyG was 0.737, which was higher than that of either index alone. Conclusion Elevated serum SII and TyG levels are associated with an increased risk of MACE after emergency PCI in ACS patients. Combined detection of these two indices demonstrates superior predictive value for postoperative MACE.更多还原