【摘要】 副鸡禽杆菌(Avibacterium paragallinarum)是引发鸡传染性鼻炎的重要病原体，其导致的急性上呼吸道炎症严重危害鸡群健康，造成鸡生长抑制、产蛋下降及高死亡率，给养禽业带来重大经济损失。近年来，我国该病流行率无明显下降趋势，且B血清型流行率持续上升，防控形势严峻。疫苗免疫是核心防控手段，但商用灭活疫苗因地方流行株与疫苗株间抗原匹配性不足，保护效力常受限。因此，亟需扩充疫苗菌株库或研发新型疫苗(如基因工程疫苗)以应对抗原异质性挑战。本文综述了副鸡禽杆菌疫苗包括灭活疫苗、减毒活疫苗、亚单位疫苗及其他疫苗的研究进展，旨在为后续疫苗的研发提供一定参考。更多还原

【Abstract】 Avibacterium paragallinarum(Av. paragallinarum),the causative agent of infectious coryza in chickens,induces severe acute upper respiratory inflammation. This disease significantly compromises flock health,resulting in growth retardation,reduced egg production,and high mortality,leading to substantial economic losses in the poultry industry. In recent years,the prevalence of this disease in China has shown no significant decline,with the prevalence of serovar B continuing to rise,posing significant challenges to control efforts. Vaccination remains the cornerstone of prevention and control of this pathogen. However,the protective efficacy of commercial inactivated vaccines is often limited due to antigenic mismatch between circulating field strains and vaccine strains. Therefore,there is an urgent need for expanding vaccine strain libraries or developing novel vaccines,such as genetically engineered vaccines,to address the challenge of antigenic heterogeneity. This review comprehensively summarizes current research on Av. paragallinarum vaccines,including inactivated vaccines,attenuated live vaccines,subunit vaccines,and other vaccine types,aiming to provide valuable references for future vaccine development.更多还原