【摘要】 病原体感染和非致病性因素可触发免疫反应，导致眼部炎症。环化酸鸟苷-腺苷酸合成酶(cGAS)-干扰素基因刺激因子(STING)通路是最近发现的一种炎症信号通路，它将双链DNA识别为激活信号，以促进炎症反应或自身免疫反应的下游细胞因子的表达。越来越多的证据表明，cGAS-STING信号转导通路在介导眼部炎症和炎症相关疾病，包括干眼、角膜炎、葡萄膜炎、青光眼、糖尿病视网膜病变和年龄相关性黄斑变性等炎症反应中起关键作用。本文就cGAS-STING通路在眼部疾病中作用的研究进行综述，以期为眼部疾病的发病机制和分子靶点提供指导。更多还原

【Abstract】 Pathogen infection and non-pathogenic factors can trigger immune responses, leading to eye inflammation.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon genes(STING) pathway is a recently discovered inflammatory signaling pathway that recognizes double-stranded DNA as an activation signal to promote the expression of downstream cytokines in inflammatory or autoimmune responses.More and more evidence has shown that the cGAS-STING signaling pathway plays a key role in mediating ocular inflammation and inflammatory diseases, including dry eye, keratitis, uveitis, glaucoma, diabetic retinopathy, and age-related macular degeneration.This article reviews the research on the role of the cGAS-STING pathway in eye diseases, in order to provide guidance for the pathogenesis and molecular targets of eye diseases.更多还原