【摘要】 目的 验证新型经皮植入搏动式左心辅助装置的合理性和可行性。方法 新型搏动式心脏辅助装置包括植入导管、外管和驱动装置。将导管前端的心室段和升主动脉段分别置于左心室及升主动脉内,两段均设有灌注侧孔,侧孔处均有特殊单向膜片阀结构。当从左心室抽血时,位于升主动脉段的小孔关闭,左心室段小孔开放;而射血时左心室段小孔关闭,升主动脉段小孔打开,从而实现脉冲式将血液从左心室抽吸至升主动脉的目的。利用体外测量装置驱动甘油水,检测新型左心辅助装置的流量。结果 该经皮植入搏动式左心辅助装置,能提供25～40次/min的脉冲频率以及超过2 L/min的流量支持。结论 该装置能提供较稳定的脉冲式流量支持,在模仿生理性搏动血流方面具有一定优势,但应进一步行动物实验以评估其合理性和可操作性。更多还原

【Abstract】 Objective To verify the rationality and feasibility of a novel percutaneously implanted pulsatile left ventricular assist device(LVAD).Methods The novel pulsatile cardiac assist device consisted of an implantable catheter, an outer tube, and a driving unit. The ventricular segment and the ascending aortic segment at the tip of the catheter were placed in the left ventricle and the ascending aorta, respectively. Both segments were equipped with perfusion side holes, and each side hole had a special one-way membrane valve structure. During blood aspiration from the left ventricle, the small holes in the ascending aortic segment closed while those in the left ventricle opened; during ejection, the small holes in the left ventricle closed while those in the ascending aorta opened, thereby achieving pulsatile blood aspiration from the left ventricle to the ascending aorta. Anin vitro measurement setup using glycerinwater solution was employed to test the flow rate of the novel left ventricular assist device.Results This percutaneously implanted pulsatile left ventricular assist device provided a pulse frequency of 25-40 beats/min and a flow support exceeding 2 L/min.Conclusion The device provides relatively stable pulsatile flow support and has certain advantages in mimicking physiological pulse flow; however, further animal experiments are needed to evaluate its rationality and operability.更多还原