【摘要】 目的 胃食管反流病(GERD)和肠易激综合征(IBS)是最常见的胃肠道疾病，GERD、IBS对患者的日常生活、工作和心理状态产生不同程度的影响。本研究将运用孟德尔随机化(MR)探究GERD与IBS两种疾病的因果关系。方法 GERD数据、IBS数据均来自GWAS数据库，分别包括1 590 227例GERD样本，病例组462 753例，对照组1 127 474例；IBS样本486 601例，病例组53 400例，对照组433 201例，以上样本均来自欧洲人群。以IVW为主要分析方法，检验GERD与IBS二者之间的因果关系。运用IVW与MR-Egger法进行异质性检验，运用MR-Egger回归截距进行多效性检验，运用“留一法”检验研究的敏感性，使用F检验是否存在弱工具变量偏倚。结果 选择GERD为暴露，以IBS为结局时，筛选并纳入191例SNP,结果提示GERD是增加IBS发生的危险因素，具有一定的因果联系(IVW法：OR=1.328,95%CI:1.269～1.390,P<0.05),进行反向MR分析得出，IBS同样会增加发生GERD的风险(IVW法：OR=1.453,95%CI:1.092～1.932,P<0.05)。结论 GERD与IBS存在双向因果关系，GERD的存在会增加IBS的风险，而IBS同样对GERD具有正向作用。更多还原

【Abstract】 Objective Gastroesophageal reflux disease(GERD) and irritable bowel syndrome(IBS) are the most common gastrointestinal diseases. GERD and IBS have different degrees of impact on patients’ daily life, work and psychological state. This study aims to explore the causal relationship between GERD and IBS using Mendelian randomization(MR). Methods GERD data and IBS data were all from the GWAS database, including 1 590 227 GERD samples(462 753 cases in the case group and 1 127 474 cases in the control group) and 486 601 cases of IBS samples(53 400 cases in the case group and 433 201 cases in the control group). The above samples were all from the European population. IVW was used as the main analysis method to test the causal relationship between GERD and IBS. IVW and MR-Egger methods were used to test heterogeneity, MR-Egger regression intercept was used to test pleiotropy, "leave one" method was used to test the sensitivity of the study, and F value was used to test whether there was weak instrumental variable bias. Results When GERD was selected as exposure and IBS was used as the outcome, 191 cases of SNPs were screened and included. Results indicated that GERD was a risk factor for the occurrence of IBS, and there was a certain causal relationship(IVW method: OR=1.328, 95% CI: 1.269-1.390, P<0.05). Reverse MR analysis showed that IBS also increased the risk of GERD(IVW method: OR=1.453, 95% CI: 1.092-1.932, P<0.05). Conclusion There is a bidirectional causal relationship between GERD and IBS. The GERD increases the risk of IBS, and IBS also has a positive effect on GERD.更多还原