【摘要】 目的 分析母亲孕期细颗粒物(Particulate Matter 2.5,PM_2.5)暴露与子代生命早期生长指标变化之间的关联。方法 选取北京大学通州出生队列（Peking University Birth Cohort in Tongzhou, PKUBC-T）中的1 666名儿童，分析其在1月龄至24月龄的7次随访的身长与体重数据，并采用体质指数（Body Mass Index, BMI）和身长别体重（Weight for Length, WFL）的生长速度、生长幅度与生长峰值指标评估儿童早期生长。利用机器学习模型计算孕期平均每日PM_2.5暴露，通过广义线性回归及广义线性混合效应模型，分析母亲孕期PM_2.5暴露和儿童早期生长发育特征的关联。结果 调整协变量后，母亲孕期PM_2.5每增加10μg/m³,儿童0～2岁期间的BMI-Z和WFL-Z生长速度分别降低0.06 （95%CI:-0.12,-0.01,P=0.029）和0.11 （95%CI:-0.17,-0.05,P=0.001）、生长幅度分别减少0.19 （95%CI:-0.33,-0.05,P=0.010）和0.32 （95%CI:-0.47,-0.17,P<0.001）;WFL达峰月龄延后4.19月（95%CI:1.88, 6.51;P<0.001）,峰值高度增加0.62 kg/m（95%CI:0.03, 1.21;P=0.038）,排除早产儿与低出生体重儿后关联依然有统计学意义。结论 母亲孕期PM_2.5暴露可降低儿童0～2岁期间的生长速度和生长幅度，提高并延后生长峰值，提示孕期PM_2.5暴露影响儿童早期生长。更多还原

【Abstract】 Objective To investigate the correlation between prenatal Particulate Matter 2.5(PM_2.5) exposure and multiple growth parameters in early childhood. Methods A total of 1,666 children from Peking University Birth Cohort in Tongzhou（PKUBC-T） were selected, and their length and weight data were recorded during 7 follow-ups from 1 month to 24 months of age. The velocity, amplitude and peak parameters of Body Mass Index（BMI） and Weight for Length（WFL） were used to assess child growth. Machine learning models were used to calculate the average daily PM_2.5 concentrations during pregnancy. Generalized linear regression and generalized linear mixed-effects models were used for the association between prenatal PM_2.5 concentration and growth indicators in children. Results After adjusting for covariates, every 10μg/m³ increase of maternal PM_2.5 exposure during pregnancy was associated with decreased growth velocities of BMI-Z and WFL-Z in children aged 0～2 years by 0.06（95% CI:-0.12,-0.01, P=0.029） and 0.11（95% CI:-0.17,-0.05, P=0.001） respectively, reduced growth amplitudes by 0.19（95% CI:-0.33,-0.05, P=0.010） and 0.32（95% CI:-0.47,-0.17, P<0.001） respectively, as well as delayed peak month by 4.19 months（95% CI:1.88, 6.51;P<0.001）, increased WFL peak by 0.62 kg/m（95% CI:0.03, 1.21;P=0.038）. These associations remained significant after excluding those preterm birth and low birth weight children. Conclusion Maternal exposure to PM_2.5 during pregnancy inhibited growth velocities and amplitudes in children aged 0～2 years, increased and delayed the WFL growth peak, indicating that prenatal PM_2.5 exposure may influence the growth of children.更多还原