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“伪装”为溃疡性结肠炎合并重症肺炎的粪类圆线虫重度感染

Severe Strongyloides stercoralis infection “masquerading” as ulcerative colitis with concomitant severe pneumonia

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【作者】 周晛; 顾剑飞; 徐斌; 卢清; 王新宇;

【Author】 ZHOU Xian;GU Jianfei;XU Bin;LU Qing;WANG Xinyu;Department of Infectious Diseases, Huashan Hospital, Fudan University;

【通讯作者】 徐斌;王新宇;

【机构】 复旦大学附属华山医院感染科;

【摘要】 本例患者存在因结节病应用糖皮质激素的既往病史,本次以腹泻起病,在肠镜及病理检查均提示溃疡性结肠炎的情况下,予以相应治疗但效果不佳,继之病情进展,出现高热气促,后经支气管肺泡灌洗液二代测序及粪便镜检均找到粪类圆线虫,经过伊维菌素积极驱虫治疗后复查肠镜完全正常,最终以粪类圆线虫感染一元论解释了患者的肠道病变,其肺部病灶也在相应抗感染治疗后明显好转。

【Abstract】 This patient had a history of glucocorticoid therapy for sarcoidosis. He presented initially with diarrhea, and both colonoscopy and histopathology suggested ulcerative colitis. Empirical treatment for ulcerative colitis yielded poor clinical response. The disease subsequently progressed, with high fever and dyspnea. Strongyloides stercoralis was later identified in both bronchoalveolar lavage fluid by next-generation sequencing and in stool specimens. Following prompt anti-helminthic therapy with ivermectin, repeat colonoscopy revealed complete normalization. Ultimately, a unifying diagnosis of Strongyloides stercoralis infection accounted for the patient’s intestinal manifestations, and his pulmonary lesions also improved significantly with appropriate anti-infective treatment.

  • 【文献出处】 上海医药 ,Shanghai Medical & Pharmaceutical Journal , 编辑部邮箱 ,2026年04期
  • 【分类号】R563.1;R574.62
  • 【下载频次】20
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