【摘要】 本研究建立了一种小鼠结肠癌脑转移模型。通过向BALB/c小鼠颈内动脉注射CT26结肠癌细胞构建模型，并应用MRI动态监测脑转移灶的形成与进展。所有小鼠均在注射过程中存活，平均生存时间为（43.7±1.2）d，脑转移建模成功率达100%。脑转移灶在第2、3、4周时的最大直径分别为（2.5±0.3）、（3.2±0.7）和（3.5±0.6）mm。病理学检查显示，脑转移灶与脑内微血管关系密切。本研究建立的模型具有稳定性高、重复性好的特点，可为进一步研究结肠癌脑转移的发生机制及相关治疗策略提供可靠的实验基础。更多还原

【Abstract】 A murine model for studying brain metastasis from colon cancer was established and identified in this study, which was established by injecting CT26 cells into its internal carotid artery. The occurrence and progress of brain metastasis were detected by MRI. None of murine model died during injection and the average survival time was(43.7±1.2) days. The success rate of brain metastasis formation reached 100%. The maximum diameter of brain metastatic lesion was(2.5±0.3),(3.2±0.7) and(3.5±0.6) mm at the second week, the third week and the fourth week, respectively. Pathological examination showed that the brain metastases were closely associated with microvessels. The animal model established in this study has the characteristics of high stability and repeatability, which can provide a reliable experimental basis for further research on the mechanism of brain metastasis from colon cancer and related treatment strategies.更多还原