【摘要】 目的 探讨腹腔镜全子宫加双附件切除术(LTHBA)治疗子宫内膜癌(EC)的临床效果。方法 选取120例EC患者，按随机数字表法分为2组，各60例。对照组腹腔镜下行广泛性子宫切除术(LRH),观察组行LTHBA。比较两组手术情况、血清炎性因子水平、肿瘤标志物、生活质量及并发症。结果 观察组手术时间、住院时间分别为(88.65±6.87)min、(10.11±1.25)d,均短于对照组[(105.74±10.57)min、(14.15±1.86)d],术中出血量为(225.63±28.65)ml,少于对照组(289.67±30.74)ml,差异有统计学意义(P<0.05);观察组术后血清炎性因子水平为(31.41±3.42)ng/ml、(15.67±1.36)mg/L、(21.05±2.34)pg/ml,均低于对照组[(35.89±3.57)ng/ml、(20.35±2.87)mg/L、(24.62±2.47)pg/ml],差异有统计学意义(P<0.05);两组术后肿瘤标志物水平相当，差异无统计学意义(P>0.05);观察组术后生活质量评分分别为(87.96±4.88)分、(86.24±5.25)分、(89.67±4.52)分、(90.48±4.56)分，均高于对照组[(82.41±5.15)分、(80.16±5.19)分、(83.48±4.43)分、(84.69±5.12)分],差异有统计学意义(P<0.05);观察组并发症发生率低于对照组，差异有统计学意义(P<0.05)。结论 LTHBA治疗EC创伤更小，可避免炎症反应过度激活，降低并发症发生风险。更多还原

【Abstract】 Objective To investigate the clinical effect of laparoscopic total hysterectomy plus double adjunctive resection(LTHBA)in the treatment of endometrial cancer(EC).Methods 120 patients with EC were selected, and were divided into 2 groups with 60 cases each according to random number table method.The control group underwent extensive laparoscopic hysterectomy(LRH),and the observation group underwent LTHBA.The operation status, serum inflammatory factors, tumor markers, quality of life and complications were compared between the 2 groups.Results The duration of operation and hospitalization in the observation group was(88.65±6.87)min and(10.11±1.25)d, which was shorter than that in the control group(105.74±10.57)min and(14.15±1.86)d, and the intraoperative blood loss was(225.63±28.65)ml.It was higher than that of the control group(289.67±30.74)ml, with statistical difference(P<0.05).Postoperative serum inflammatory factor levels in the observation group were(31.41±3.42)ng/ml,(15.67±1.36)mg/L,(21.05±2.34)pg/ml.It was lower than that of the control group(35.89±3.57)ng/ml,(20.35±2.87)mg/L,(24.62±2.47)pg/ml, with statistical difference(P<0.05).There was no significant difference in the level of tumor markers between the 2 groups(P>0.05).The postoperative quality of life scores of the observation group were(87.96±4.88),(86.24±5.25),(89.67±4.52),(90.48±4.56).It was higher than that of control group(82.41±5.15)points,(80.16±5.19)points,(83.48±4.43)points,(84.69±5.12)points, and there were statistical differences(P<0.05).The complications in the observation group were less than those in the control group, with statistical difference(P<0.05).Conclusion LTHBA treatment of EC is less traumatic, can avoid overactivation of inflammatory response, reduce the risk of complications.更多还原