【摘要】 血脂异常是动脉粥样硬化(AS)及多种心脑血管、代谢性疾病的关键病理基础与共同危险因素，其发病常非孤立存在，而是与高血压、糖尿病、肥胖等多重代谢紊乱及心脑血管事件相互交织、恶性循环，形成涉及炎症反应、氧化应激、免疫失衡等多通路、多靶点的复杂网络机制，临床辨治面临挑战。上海市名中医、颜氏内科传承人颜乾麟教授，立足于流派“气血理论”及多年临证实践，系统构建了以“气血失衡所致脾虚痰瘀”为核心病机、以“调气和血”为根本治则的调脂稳斑辨治体系。指出“气血失衡”是多重疾病背景下脂代谢紊乱的中医本质，强调“脾虚”致清浊不辨为发病之源。以调气和血为核心，采用健脾运脾(益气行气)、升清泄浊、疏肝行气、辛开苦降、活血化瘀等方法，体现动静结合、气血同治、标本兼顾特色，在多重疾病中发挥降脂稳斑作用。在此基础上，凝练核心经验方“颜氏运脾调脂方”,通过益气健脾、活血化痰、升清降浊，实现调脂斑块、改善内环境的综合效应。颜乾麟教授的经验为临床应对复杂因素下的血脂异常与动脉粥样硬化提供了系统的中医理论指导与可操作的实践方案，体现了中医“异病同治”、整体调节的优势，不仅丰富了血脂异常辨治理论，对提高临床治疗心脑血管及代谢性复杂共病具有一定的指导价值。更多还原

【Abstract】 Dyslipidemia was a key pathological basis and common risk factor for atherosclerosis(AS) and various cardiovascular, cerebrovascular and metabolic diseases.Its onset was often not isolated but interwoven with multiple metabolic disorders such as hypertension, diabetes, and obesity, as well as cardiovascular and cerebrovascular events, forming a complex network mechanism involving multiple pathways and targets such as inflammatory response, oxidative stress, and immune imbalance, posing challenges for clinical diagnosis and treatment.Professor YAN Ganlin, a renowned traditional Chinese medicine expert in Shanghai and an inheritor of the YAN school of internal medicine, based on the school’s Qi and blood theory and years of clinical practice, has systematically constructed a lipid regulation and plaque stabilization diagnosis and treatment system with Qi and blood imbalance leading to spleen deficiency, phlegm and blood stasis as the core pathogenesis and regulating Qi and blood as the fundamental treatment principle.He pointed out that Qi and blood imbalance was the essence of lipid metabolism disorder in the context of multiple diseases, emphasizing that spleen deficiency causing inability to distinguish clear from turbid was the source of the disease.Centering on regulating Qi and blood, adopted methods such as strengthening and regulating the spleen(tonifying Qi and promoting Qi circulation),elevating clear and purging turbid, soothing the liver and promoting Qi circulation, pungent opening and bitter purging, and activating blood and resolving stasis, demonstrating the characteristics of combining dynamic and static, treating Qi and blood simultaneously, and addressing both symptoms and root causes.This approach plays a role in lipid regulation and plaque stabilization in multiple diseases.On the basis, he refined the core experience formula YAN’s spleen regulation and lipid regulation formula, which achieves a comprehensive effect of regulating lipid and plaque and improving the internal environment through tonifying Qi and strengthening the spleen, activating blood and resolving phlegm, elevating clear and purging turbid.Professor YAN Ganlin’s experience provides systematic theoretical guidance and practical solutions for clinical management of dyslipidemia and atherosclerosis under complex factors, demonstrating the advantages of traditional Chinese medicine in treating different diseases with the same therapy and holistic regulation.It not only enriches the theory of dyslipidemia diagnosis and treatment but also has significant guiding value for the clinical treatment of complex co-morbidities of cardiovascular and cerebrovascular and metabolic diseases.更多还原