【摘要】 非染色体结构维持亚单位凝聚素Ⅱ复合亚基D3(non-structural maintenance of chromosomes condensinⅡcomplex subunit D3,NCAPD3)是凝缩蛋白复合物Ⅱ的亚基之一，在细胞有丝分裂染色体的凝集和分离过程中发挥重要作用。NCAPD3在多种恶性肿瘤组织中呈高表达，与肿瘤的发生、发展及不良预后密切相关。本文就NCAPD3的表达异常与肿瘤之间的相关性作一综述，以期为NCAPD3作为肿瘤新靶点的临床转化治疗和新型药物研发提供思路。更多还原

【Abstract】 Non-structural maintenance of chromosomes condensin Ⅱ complex subunit D3(NCAPD3) is one of the subunits of condensin complexⅡ, which plays an important role in the process of mitotic chromosome condensation and segregation.NCAPD3 is highly expressed in a variety of malignant tumor tissues, closely related to tumor occurrence, development and poor prognosis. In this paper, the correlation between NCAPD3 abnormal expression and tumors was reviewed, with a view to providing ideas for the clinical translational therapy and novel drug development of NCAPD3 as a new target of tumors.更多还原