【摘要】 作为一类能够有效抑制肿瘤生长的信号传导通路，环鸟苷磷酸-腺苷磷酸合酶-干扰素基因刺激因子(cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene, cGAS-STING)通路正日益引起人们的关注。该通路通过识别从细胞核/线粒体泄漏到细胞质中的异常双链DNA(double-stranded DNA,dsDNA),能够增强机体免疫反应，调节重塑肿瘤微环境，诱导肿瘤细胞的死亡。具体途径包括激活树突状细胞(dendritic cells, DC)、活化CD8~+T细胞、识别肿瘤细胞抗原、增强肿瘤微环境中自然杀伤细胞(natural killer, NK)浸润等。靶向激活该通路的STING激动剂对肿瘤的治疗发挥至关重要的作用。靶向治疗与免疫治疗的联合应用有可能极大提升整体治疗效果。本文阐述了cGAS-STING通路的信号转导途径，对其在激动剂靶向治疗与免疫治疗2个领域的作用进行综述，并系统总结了该通路相关疗法与传统疗法、免疫检查点抑制剂等疗法的联用治疗优势与潜在负面作用，为临床应用提供理论指导。更多还原

【Abstract】 The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes(cGAS-STING) pathway, as a class of signaling cascades capable of effectively suppressing tumor growth, is increasingly attracting people’s attention. By detecting aberrant cytoplasmic dsDNA originating from the nucleus or mitochondria, this pathway enhances immune responses, remodels the tumor microenvironment, and ultimately induces tumor cell death. The specific mechanisms include activating dendritic cells(DCs) and CD8~+ T cells, promoting the recognition of tumor antigen, and enhancing the infiltration of natural killer(NK) cells in the tumor microenvironment. Furthermore, STING agonists that target and activate this pathway play a pivotal role in cancer therapy. The synergistic application of targeted therapy and immunotherapy holds significant potential to substantially improve overall treatment efficacy. This article will outline the signal transduction pathway of the cGAS-STING pathway, review its roles in agonist-targeted therapy and immunotherapy, systematically summarize the therapeutic advantages and potential adverse effects of combining cGAS-STING-related therapies with conventional treatments and immune checkpoint inhibitors, and provide theoretical guidance for clinical applications.更多还原