【摘要】 矽肺合并系统性硬化症（Erasmus综合征）为一种罕见疾病，临床表现复杂，涉及多系统损害，预后较差。本文报道1例44岁Erasmus综合征合并真菌性肺炎及呼吸衰竭患者，经过免疫抑制、抗真菌、抗纤维化、无创机械通气等综合治疗后好转出院，结合文献进行讨论分析，以提高临床医生对该疾病的认识。在临床工作中对Si O₂暴露人群需关注其是否合并系统性硬化症，以期做到早期诊断和治疗，改善预后。对接尘人群做好防尘措施是预防Erasmus综合征的关键。更多还原

【Abstract】 Silicosis combined with systemic sclerosis (Erasmus syndrome) is a rare disease with complex clinical manifestations,mult-system damage,and poor prognosis.This article reports a 44-year-old patient with Erasmus syndrome complicated with fungal pneumonia and respiratory failure. After comprehensive treatment including immunosuppression,antifungal therapy,anti-fibrosis therapy,and non-invasive mechanical ventilation,the patient improved and was discharged.In clinical practice,clinicians should pay close attention to whether patients with silicosis are complicated with systemic sclerosis,so as to achieve early diagnosis,timely treatment and improve prognosis.Dust control measures are the key to prevent Erasmus syndrome.更多还原