【摘要】 目的：分析慢性肾脏病(CKD)维持性血液透析(MHD)患者睡眠障碍的相关因素，并制定干预对策。方法：选取2024年1月至2025年8月山东大学齐鲁医院肾内科接受MHD的CKD患者80例作为研究对象，按睡眠障碍情况分为障碍组(n=49)和无障碍组(n=31)。收集患者临床资料、血磷、血清白蛋白(Alb)、广泛性焦虑障碍量表(GAD-7)评分、汉密尔顿抑郁量表(HAMD)评分、斯坦福嗜睡量表(SSS)评分。多因素分析筛选睡眠障碍危险因素。结果：障碍组年龄、血磷水平、透析时长、不宁腿综合征(RLS)、睡眠呼吸暂停(SAS)发生率、GAD-7评分、HAMD评分、SSS评分高于无障碍组，Alb水平低于无障碍组(P<0.05);并发RLS、并发SAS、HAMD评分升高、血磷水平升高、Alb降低是MHD患者睡眠障碍的危险因素(P<0.05)。结论：RLS、SAS、抑郁、血磷升高及低血清白蛋白与MHD患者睡眠障碍有关，可通过优化透析方案、加强情绪疏导、限制高磷饮食、补充优质蛋白改善睡眠质量。更多还原

【Abstract】 Objective:To analyze the risk factors of sleep disorders in patients with chronic kidney disease(CKD) undergoing maintenance hemodialysis(MHD) and to propose corresponding intervention strategies.Methods:A total of 80 CKD patients receiving MHD in the Department of Nephrology of Qilu Hospital of Shandong University from January 2024 to August 2025 were selected as the study subjects.According to the presence of sleep disorders, the patients were divided into a sleep disorder group(n=49) and a non-sleep disorder group(n=31).Clinical data, serum phosphorus, serum albumin(Alb),Generalized Anxiety Disorder Scale(GAD-7) score, Hamilton Depression Scale(HAMD) score, and Stanford Sleepiness Scale(SSS) score were collected.Multivariate analysis was performed to identify the risk factors for sleep disorders.Results:The age, serum phosphorus level, dialysis duration, incidence of restless legs syndrome(RLS),incidence of sleep apnea syndrome(SAS),GAD-7 score, HAMD score, and SSS score in the sleep disorder group were higher than those in the non-sleep disorder group, while the Alb level was lower than that in the non-sleep disorder group(P<0.05).Complicated RLS,complicated SAS,elevated HAMD score, increased serum phosphorus level, and decreased Alb level were identified as risk factors for sleep disorders in MHD patients(P<0.05).Conclusion:RLS,SAS,depression, elevated serum phosphorus, and low serum albumin are associated with sleep disorders in MHD patients.Optimizing dialysis regimens, strengthening emotional counseling, restricting high-phosphorus diets, and supplementing high-quality protein may help improve sleep quality.更多还原