【摘要】 目的 探讨肾内科尿路感染患者的临床特征及血清诱骗受体3(DCR3)、β-防御素-3(HBD??3)、尿液信号传导与转录激活因子3(STAT3)、肝素结合蛋白（HBP）水平变化，以期为今后临床诊治提供参考。方法 选取2021年1月-2024年12月郑州市第七人民医院收治的肾内科合并尿路感染患者96例作为感染组，同期选取郑州市第七人民医院收治的肾内科未合并尿路感染患者96例作为未感染组。比较两组临床特征、DCR3、HBD??3、STAT3、HBP水平，分析肾内科患者尿路感染的危险因素，以及上述标志物的诊断价值。结果 感染组年龄≥50岁、合并糖尿病、有尿路梗阻及住院时间≥15 d占比高于未感染组，差异均有统计学意义（χ~2=17.538、8.168、11.021、20.023,P均<0.05）。感染组血清DCR3、HBD??3、尿液STAT3、HBP水平高于未感染组，差异均有统计学意义（t=10.259、10.903、10.316、9.148,P均<0.05）。年龄≥50岁、合并糖尿病、有尿路梗阻、住院时间≥15 d及上述标志物水平均是肾内科患者尿路感染的独立危险因素（P均<0.05）。受试者工作特征（ROC）曲线分析显示，上述标志物联合检测诊断肾内科患者尿路感染的曲线下面积（AUC）高于各指标单独检测，差异有统计学意义（P<0.05）。结论 肾内科尿路感染患者具有年龄大、合并糖尿病、有尿路梗阻及住院时间长的特点，且患者血清DCR3、HBD??3及尿液STAT3、HBP呈高表达，四者联合诊断肾内科尿路感染的价值更高。更多还原

【Abstract】 Objective To investigate the clinical characteristics and changes in serum levels of decoy receptor 3(DCR3), β??defensin??3(HBD??3), urinary signal transducer and activator of transcription 3(STAT3), and heparin??binding protein(HBP) of patients with urinary tract infections in the department of nephrology,in order to provide a reference for future clinical diagnosis and treatment. Methods 96 cases of patients with combined urinary tract infection in nephrology admitted to the Zhengzhou Seventh People’ Hospital from January 2021 to December 2024 were selected as the infected group, and 96 patients with uncomplicated urinary tract infection in nephrology admitted to the Zhengzhou Seventh People’ Hospital during the same period were selected as the uninfected group. The clinical characteristics, DCR3, HBD??3, STAT3 and HBP between the two groups were compared; the risk factors of urinary tract infection in patients with nephrology, and the diagnostic value of the above markers were analyzed. Results In the infected group, the percentage of age ≥50 years, combined diabetes mellitus, with urinary tract obstruction, and hospitalization time ≥15 d were higher than those in the uninfected group(χ~2=17.538,8.168,11.021,20.023;all P<0.05); and the levels of serum DCR3, HBD ?? 3, urinary STAT3, and HBP were higher than those in the uninfected group(t=10.259, 10.903, 10.316, 9.148;all P<0.05). Age ≥50 years, diabetes mellitus, urinary tract obstruction, hospital stay ≥15 days, and the levels of the above ?? mentioned biomarkers were all independent risk factors for urinary tract infection in nephrology patients(all P<0.05). Receiver operating characteristic(ROC) curve analysis showed that the area under the curve(AUC) for the combined detection of the above biomarkers in diagnosing urinary tract infection in nephrology patients was higher than that for individual biomarkers, and the difference was statistically significant(P<0.05). Conclusions Patients with urinary tract infections in the nephrology department were characterized by advanced age, diabetes, urinary tract obstruction, and long hospital stays. In addition, these patients showed high expression of serum DCR3, HBD??3, and urinary STAT3 and HBP. The diagnostic value of the combined of these four factors for urinary tract infections was higher than that of any single factor.更多还原