【摘要】 目的 调查深圳市2023年社区人群百日咳抗体水平，评价人群百日咳免疫状况，为持续优化百日咳防控策略提供依据。方法 应用多阶段分层抽样法，在深圳市若干社区选择参与者，采集2 312份血清样本，使用酶联免疫吸附试验检测百日咳毒素IgG抗体（PT-IgG）。分析不同区域、性别、年龄组之间抗体浓度和阳性率差异。结果 采集2 312名参与者血清，其中男1 080名，女1 232名，福田区1 368名，南山区944名。人群PT-IgG几何平均浓度（GMC）为9.84 IU/mL,2～<4岁组GMC水平最高为18.74 IU/mL,13～<16岁组最低为5.71 IU/mL。百日咳抗体总阳性率（≥100 IU/mL）为2.20%，浓度低于检出限值（<5 IU/mL）个案占31.49%。福田区和南山区人群抗体GMC水平分别为7.85和13.63 IU/mL，差异有统计学意义（U=476 420.500,P<0.001），不同年龄组抗体GMC和阳性率差异均有统计学意义（H=59.907，χ~2=82.830,P均<0.001）。结论 深圳社区人群的百日咳抗体GMC总体水平较低，儿童青少年感染风险增加，建议加强病例对照研究，以科学评价免疫策略改变的效果，提升百日咳防控水平。更多还原

【Abstract】 Objective To investigate the pertussis antibody levels in the community population of Shenzhen in 2023, evaluate the population’s pertussis immune status, and provide practical evidence for the continuous optimization of pertussis prevention and control strategies. Methods Participants were selected from several communities in Shenzhen using a multistage stratified sampling method. A total of 2 312 serum samples were collected, and the IgG antibody against pertussis toxin(PT-IgG) was detected by enzyme-linked immunosorbent assay(ELISA). Analysis of the difference of antibody concentration and positive rate among different regions, genders and age groups. Results A total of 2 312 participants’ serum samples were collected for the study, including 1 080 males and 1 232 females. Among them,1 368 were from Futian district and 944 were from Nanshan district. The geometric mean concentration(GMC) of PT-IgG in the population was 9.84 IU/mL. The 2-<4 age group had the highest GMC of 18.74 IU/mL, while the 13-<16 age group had the lowest GMC of 5.71 IU/mL. The total positive rate of pertussis antibodies （≥100 IU/mL） was 2.20%, and cases with concentrations below the detection limit(<5 IU/mL) accounted for 31.49%. The antibody GMC in Futian district and Nanshan district were 7.85 and 13.63 IU/mL, respectively, showing a statistical difference(U=476 420.500, P<0.001). There were statistical differences in antibody GMC and positive rates among different age groups(H=59.907, χ~2=82.830; all P<0.001). Conclusions The overall GMC of pertussis antibodies in the community population of Shenzhen was low, and the risk of pertussis infection among children and adolescents had increased. It was recommended to strengthen case-control studies to scientifically evaluate the effects of changes in immunization strategies and improve the pertussis prevention and control level.更多还原