【摘要】 目的 探究血清抑制素B(INH-B)、性激素、一氧化氮(NO)、内皮素(ET)水平与精索静脉曲张(VC)患者精液质量的相关性。方法 回顾性分析2020年12月至2022年12月本院收治的60例VC患者的临床资料,并按1∶1比例选取同期体检健康者60名为对照组,比较两组精子质量指标、血清抑制素B(INH-B)、性激素、NO、ET,并分析其诊断VC的效能,以及与VC患者病情严重程度和精子质量的相关性。结果 受试者工作特征(ROC)曲线分析血清INH-B、卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)、NO、ET诊断VC的AUC分别为0.727、0.740、0.749、0.835、0.843、0.825。(Spearman)相关性分析显示,FSH、LH、NO、ET与VC患者严重程度呈正相关,与精子浓度、精子活力呈负相关(P<0.05);T、INH-B与VC患者严重程度呈负相关,与精子浓度、精子活力呈正相关(P<0.05)。结论 血清INH-B、性激素、NO、ET水平在VC患者血清中异常表达,与病情严重程度、精液质量存在相关,可作为判断VC合并男性不育的指标。更多还原

【Abstract】 Objective To explore the correlations between serum inhibin B(INH-B), sex hormones, nitric oxide(NO), endothelin(ET) and semen quality in patients with varicocele(VC).Methods A retrospective study was conducted on 60 patients with VC treated in our hospital from December 2020 to December 2022. Sixty healthy individuals undergoing routine physical examination during the same period were selected as the control group at a 1 ∶ 1 ratio. Semen quality parameters and serum biochemical factors, including INH-B, sex hormones, NO, and ET, were compared between the two groups. The diagnostic performance of these serum biochemical factors for VC was evaluated. Correlations between serum INH-B, sex hormones, NO, and ET levels and disease severity as well as semen quality in VC patients were analyzed.Results Receiver operating characteristic(ROC) analysis showed that the area under the curve(AUC) values of serum INH-B, FSH, LH, testosterone(T), NO, and ET for diagnosing VC were 0. 727, 0. 740, 0. 749, 0. 835, 0. 843, and 0. 825, respectively. Spearman correlation analysis showed that FSH, LH, NO, and ET were positively correlated with the severity of the patients with VC, and negatively correlated with the concentration of spermatozoa and the viability of spermatozoa(P< 0. 05); T and INH-B were negatively correlated with the severity of VC patients and positively correlated with sperm concentration and sperm viability(P< 0. 05).Conclusion Serum levels of INH-B, sex hormones, NO, ET were abnormally expressed in patients with VC, and are correlated with disease severity and semen quality. These factors can serve as reliable biomarkers for diagnosing VC-related male intertility.更多还原