【摘要】 目的：研究火针温通法、苍耳子酊与复方甘草酸苷联合应用对白癜风患者皮损及Th17/Treg免疫失衡的影响。方法：选取2023年12月1日-2024年4月30日于笔者医院就诊的符合研究条件的70例白癜风患者，以随机数字表法随机分为对照组和观察组，各35例。对照组采用苍耳子酊与复方甘草酸苷治疗，观察组在对照组基础上采用火针温通法进行联合治疗。治疗过程持续12周。比较两组皮损情况[白癜风面积评分指数(VASI)、皮损色素积分]、免疫炎症相关指标[辅助性T细胞17(Th17)、调节性T细胞(Treg)、Th17/Treg和干扰素-γ(IFN-γ)、白介素-17(IL-17)]、氧化应激指标[超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、血红素氧合酶-1(HO-1)]；统计两组患者不良反应发生率和复发率。结果：治疗后，观察组VASI下降且低于对照组，皮损色素积分升高且高于对照组(P<0.05)；两组Th17细胞含量、IFN-γ和IL-17治疗后下降，Treg细胞含量上升，观察组变化幅度高于对照组(P<0.05)；观察组SOD、CAT和HO-1水平治疗后高于对照组(P<0.05)。观察组不良反应发生率和复发率与对照组差异无统计学意义(P>0.05)。结论：火针温通法协同苍耳子酊外用，同时口服复方甘草酸苷可显著减少白癜风患者皮损面积，降低免疫反应和活性氧对色素细胞损伤。更多还原

【Abstract】 Objective To study the influence of fire needle warming method and xanthium tincture combined with compound glycyrrhizin on skin lesion status and Th17/Treg immune imbalance in patients with vitiligo.Methods A total of 70 vitiligo patients who met the study criteria and visited the author’s hospital From December 1,2023 to April 30,2024 were selected and randomly assigned to a control group and an observation group,with 35 cases in each group.The control group received xanthium tincture and compound glycyrrhizin,whereas the observation group was combined with fire needle warming method on the basis of the control group.The treatment lasted for 12 weeks.The skin lesion status[Vitiligo Area Scoring Index (VASI),skin pigment score],immune inflammation-related indicators[helper T cell 17 (Th17),regulatory T cell (Treg),Th17/Treg,interferon-γ (IFN-γ),interleukin-17 (IL-17)]and oxidative stress indicators[superoxide dismutase (SOD),catalase (CAT),heme oxygenase-1 (HO-1)]were compared between groups.The incidence rates of adverse reactions and recurrence rate in the two groups were counted.Results After treatment,the VASI in the observation group decreased and was lower than that in the control group,and the pigment score of skin lesions increased and was higher than that in the control group (P<0.05).The Th17 cell,IFN-γ and IL-17 were reduced in both groups after treatment while the Treg cell was risen,and the changes were higher in the observation group (P<0.05).The levels of SOD,CAT and HO-1 in the observation group after treatment were higher compared to the control group (P<0.05).There were no differences in the incidence rates of adverse reactions and recurrence rate between the observation group and the control group (P>0.05).Conclusion Fire needle warming method combined with xanthium tincture for external application and oral administration of compound glycyrrhizin can significantly reduce the skin lesion area of patients with vitiligo,reduce the immune response and reactive oxygen species damage to pigment cells.更多还原