【摘要】 报告1例乳头状汗管囊腺癌(SCACP)患者。患者女，27岁，先天性头皮肿物27年，近2年出现表面破溃、结痂。病理检查显示肿瘤呈浸润性生长，伴基底样及鳞状分化，免疫组化示BerEP4(+)、EMA(+)、P40(+)、GCDFP-15(+)、CK7(+)、Ki-67(10%+)。本文还结合文献系统阐述SCACP的流行病学特征、临床病理特点、免疫组化诊断标准及鉴别诊断要点，探讨该病的分期原则、手术治疗策略(包括淋巴结清扫指征)、放疗及化疗的临床意义、NGS检测在靶向治疗选择中的应用价值，并分析影响预后的关键因素及提高生存率的策略，旨在为临床诊疗提供参考。更多还原

【Abstract】 This article reports a case of SCACP in a 27-year-old female with a congenital scalp mass for 27 years, which exhibited surface ulceration and crusting in the recent 2 years. Pathological examination revealed infiltrative growth of the tumor with basaloid and squamous differentiation. Immunohistochemistry showed BerEP4(+), EMA(+), P40(+), GCDFP-15(+), CK7(+), and Ki-67(10%+). This article also systematically reviews the epidemiological characteristics, clinicopathological features, immunohistochemical diagnostic criteria and differential diagnosis of SCACP. In addition, it discusses the principles of staging, surgical treatment strategies(including indications for lymph node dissection),the clinical significance of radiotherapy and chemotherapy, and the application value of NGS testing in targeted therapy selection. Furthermore, it analyzes the key factors affecting prognosis and strategies for improving survival rate, aiming to provide reference for clinical diagnosis and treatment.更多还原