【摘要】 1例42岁男性患者主因胸闷、气促就诊,CT提示双肺弥漫性间质改变。抗感染、糖皮质激素及免疫抑制剂治疗无效,患者出现顽固性低氧血症,有创机械通气后氧合仍不佳,诊断为快速进展性间质性肺病(RP-ILD)伴Ⅰ型呼吸衰竭。行静-静脉(VV)体外膜肺氧合(ECMO)支持,氧合改善后在专科医院完成静-动-静脉(VAV)ECMO辅助下同种异体双肺移植术。术后第1日撤除ECMO机,第9日拔除气管插管。病理提示纤维化型非特异性间质性肺炎(NSIP)伴透明膜形成。患者术后出现获得性肌无力,经康复训练后肌力恢复。随访示患者移植肺功能良好。该病例诊治结果提示ECMO可作为RP-ILD患者肺移植的有效桥接手段。更多还原

【Abstract】 A 42-year-old male with chest tightness and dyspnea was admitted to the hospital. Chest CT indicated diffuse interstitial lung infiltration. Despite receiving anti-infective therapy, glucocorticoid therapy, and immunosuppressive agents, the patient developed refractory hypoxaemia. Endotracheal intubation and invasive mechanical ventilation failed to improve oxygenation. Therefore the patient was diagnosed with rapidly progressive interstitial lung disease(RP-ILD) accompanied by type Ⅰ respiratory failure. Veno-venous(VV) extracorporeal membrane oxygenation(ECMO) was initiated, and oxygenation improved in this patient. The patient subsequently underwent bilateral lung transplantation with veno-arterio-venous(VAV) ECMO support.ECMO machine was withdrawn on day 1, and extubation was achieved on day 9 after surgery. Histopathology revealed fibrotic nonspecific interstitial pneumonia(NSIP) with hyaline membrane formation. The patient developed ICU-acquired myasthenia and received early rehabilitation, with gradual recovery of muscle strength. During follow-up, graft lung function remained stable. This case demonstrates that ECMO can serve as a bridge to lung transplantation in RP-ILD patients.更多还原