【摘要】 本病例报告了1例以早发闭经和新发血压波动为主要临床表现的皮质醇增多症患者。该患者未表现出向心性肥胖、皮肤紫纹等典型的皮质醇增多症特征，导致诊断延迟长达两年。此案例强调了库欣综合征临床表现的异质性，并提醒临床医生在面对原因不明的血压波动和年轻女性闭经时，即使缺乏典型库欣综合征样体征，也应考虑内分泌性高血压以及下丘脑-垂体-肾上腺轴功能异常的可能性，将其纳入鉴别诊断范围。更多还原

【Abstract】 This case report presents a patient with Cushing’s syndrome whose main clinical manifestations were "new-onset blood pressure fluctuations and early-onset amenorrhea". The patient did not show typical features of Cushing’s syndrome such as central obesity and skin striae, which led to a delay in diagnosis for as long as two years. This case highlights the heterogeneity of clinical manifestations of Cushing’s syndrome and reminds clinicians that when facing "unexplained blood pressure fluctuations and amenorrhea in young women", even in the absence of typical Cushing’s syndrome-like signs, the possibility of endocrine hypertension and hypothalamic-pituitary-adrenal axis dysfunction should be considered and included in the differential diagnosis.更多还原