【摘要】 目的:建立并验证非小细胞肺癌(non-small cell lung cancer, NSCLC)术后患者焦虑/抑郁风险的列线图预测模型。方法:选择2021年1月至2024年12月宜宾市第二人民医院手术治疗的NSCLC患者564例，采用汉密尔顿焦虑量表和汉密尔顿抑郁量表评估患者焦虑/抑郁发生率，分析发生焦虑/抑郁的影响因素，按2∶1配比将所有患者分为模型组(376例)和内部验证组(188例),收集2025年1月至6月的75例NSCLC患者作为外部验证组，模型组数据用于构建列线图模型，并评价其校准度与区分度。结果:NSCLC术后患者焦虑/抑郁发生率为48.6%,肿瘤-淋巴结-转移临床分期、疼痛视觉模拟评分、社会支持评定量表评分、匹兹堡睡眠质量指数量表评分、核心生活质量测评量表功能评分和简化版恐惧疾病进展量表评分与NSCLC术后焦虑/抑郁发生风险有关，其OR分别为0.248、0.807、1.111、0.917、1.068和0.939。基于此建立的列线图模型有良好的校准度和区分度，模型组、内部验证组和外部验证组的最大偏移量分别为0.027(P=0.894)、0.040(P=0.877)和0.039(P=0.812),受试者工作特征曲线下面积分别为0.945、0.940和0.832。结论:该列线图预测模型能较好预测NSCLC术后患者焦虑/抑郁的发生风险。更多还原

【Abstract】 Objective: To establish and validate a nomogram prediction model for predicting anxiety/depression risk in postoperative patients with non-small cell lung cancer(NSCLC). Method:From January 2021 to December 2024,564 NSCLC patients underwent surgery at the second people’s hospital of Yibin were selected to evaluate anxiety/depression by Hamilton anxiety scale and Hamilton depression scale, and the influencing factors of anxiety/depression were analysed.All patients were divided into a model group(376 cases) and an internal validation group(188 cases) at a 2∶1 ratio.Seventy-five NSCLC cases were collected as an external validation group from January to June 2025.The data from the model group were used to construct a nomogram model and evaluate its calibration and discrimination. Results:The incidence of anxiety/depression in NSCLC postoperative patients was 48.6%.Tumor-node-metastasis clinical stage, visual analogue scale score, social support rating scale(SSRS)score, Pittsburgh sleep quality index score, quality of life questionnaire-Core 30 functional score, and fear of progression questionnaire-short form score were related with the risk of anxiety/depression in postoperative NSCLC patients, with OR values of 0.248,0.807,1.111,0.917,1.068 and 0.939,respectively.The established nomogram model based on these factors has good calibration and discrimination.The maximum offsets of the model group, internal validation group, and external validation group are 0.027(P=0.894),0.040(P=0.877),and 0.039(P=0.812),respectively.The areas under the receiver operating characteristic curve are 0.945,0.940,and 0.832,respectively. Conclusion:The nomogram prediction model can effectively predict the risk of anxiety/depression in postoperative NSCLC patients.更多还原