【摘要】 丁型肝炎病毒（HDV）作为一种缺陷病毒，需依赖乙型肝炎病毒（HBV）的包膜蛋白完成复制与传播。慢性乙型肝炎患者合并HDV感染后可导致肝脏疾病进展速度显著加快，肝硬化、肝细胞癌发生风险较单纯慢性乙型肝炎患者高出数倍，给患者生命健康带来严重威胁。当前HDV筛查覆盖率有待提升，部分HBV/HDV合并感染者未被及时发现。因此，强化临床医师对HDV的认识，扩大HDV筛查范围，及早识别感染病例并给予规范抗病毒治疗及长期随访管理，对改善患者预后、减轻疾病负担、提高患者生活质量以及实现全球“2030年消除病毒性肝炎公共卫生危害”目标具有重要意义。更多还原

【Abstract】 Hepatitis D virus(HDV), as a defective virus, relies on the envelope protein of hepatitis B virus(HBV) to complete replication and transmission. Chronic hepatitis B(CHB) patients comorbid with HDV infection may experience significant acceleration of liver disease progression and a significantly higher risk of serious complications such as liver cirrhosis and hepatocellular carcinoma(HCC) compared with the patients with CHB alone, which poses a serious threat to the life and health of patients. At present, the coverage rate of HDV screening needs to be improved, and some patients with HBV/HDV co-infection have not been found in time. Therefore, strengthening the understanding of HDV among clinicians, expanding the scope of HDV screening, identifying patients with infection in a timely manner, and performing standardized antiviral therapy and long-term follow-up management are of great significance for improving the prognosis of patients, reducing disease burden, improving the quality of life of patients, and achieving the global goal of “eliminating viral hepatitis as a public health threat by 2030”.更多还原