【摘要】 目的：本研究旨在建立一种尿酸代谢途径与人类接近且贴合人类饮食习惯的鸽子高尿酸血症(HUA)模型，为HUA机制研究干预方案筛选提供更具临床转化价值的实验载体。方法：选取20只10月龄左右健康成年雄性信鸽，随机分为4组，每组5只：A组喂养动物源(豆粕+石粉)高钙高蛋白饲料，B组喂养人类饮食源(钙片+豆浆粉)高钙高蛋白饲料(常规剂量),C组喂养人类饮食源(钙片+豆浆粉)高钙高蛋白饲料(低剂量),D组喂养常规饲料。实验周期为4周，每周检测体质量、踝关节周径及血清尿酸值。结果：A、B、C组造模4周时血清尿酸值均显著高于D组(P<0.001),且A组和B组血清尿酸水平无显著差异(P>0.05),B组与C组之间存在剂量效应差异(P<0.001),体质量和踝关节周径在各组间无显著变化。结论：本研究成功构建了基于人类饮食源饲料的鸽子HUA模型，且模型特征与人类HUA的病理进程高度相似。更多还原

【Abstract】 Objective: This study aimed to establish a pigeon hyperuricemia HUA model with a uric acid metabolism pathway similar to that of humans and in line with human dietary habits, providing an experimental carrier with greater clinical translational value for mechanism research and intervention strategy screening of hyperuricemia. Methods: Twenty healthy adult male homing pigeons aged around 10 months were selected and randomly divided into 4 groups, with 5 pigeons in each group: Group A was fed with animal-source(soybean meal + stone powder) high-calcium and high-protein feed; Group B was fed with human dietary-source(calcium tablets + soy milk powder) high-calcium and high-protein feed(conventional dose); Group C was fed with human dietary-source(calcium tablets + soy milk powder) high-calcium and high-protein feed(low dose); Group D was fed with conventional feed. The experimental period was 4 weeks, and body weight, ankle joint circumference and serum uric acid levels were measured weekly. Results: At 4 weeks of modeling, the serum uric acid levels in Groups A, B and C were significantly higher than those in Group D(P<0.001). There was no significant difference in serum uric acid levels between Group A and Group B(P>0.05), and there was a dose-effect difference between Group B and Group C(P<0.001). There were no significant changes in body weight and ankle joint circumference among the groups. Conclusion: This study successfully constructed a pigeon hyperuricemia(HUA) model based on human dietary-source feed, and the model characteristics were highly similar to the pathological process of human hyperuricemia.更多还原