【摘要】 作为一种高度模拟组织器官结构与功能的体外三维（3D）模型，类器官具有重要价值。综述了类器官生物制造技术的研究进展：该技术不仅实现了单个类器官的精准构建与高通量制备，还推动了多类器官的功能化组装，为构建大尺度复杂组织结构奠定基础。归纳了发展趋势聚焦于多工艺融合、多模态检测分析及自动化智能系统等前沿方向。梳理了类器官生物制造技术应用在疾病建模与机制解析、再生医学与组织修复、个性化治疗与药物开发，以及太空微重力环境等研究领域。针对中国现状，提出生物材料创新、装备技术升级及推动临床转化路径的改进策略，旨在加速中国类器官生物制造技术的创新与应用。更多还原

【Abstract】 As three-dimensional(3D) in vitro models, organoids recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. This review summarizes recent advances in organoid biofabrication technology. It identifies key development trends focusing on cutting-edge directions such as multi-process integration, multimodal detection and analysis, and automated intelligent systems. Furthermore, it discusses the application progress of organoid biofabrication in disease modeling and mechanistic insights, regenerative medicine and tissue repair, personalized therapeutics and drug development, as well as research in space microgravity environments. Addressing the current landscape in China, this review proposes improvement strategies focusing on biomaterial innovation, equipment technology advancement, and clinical translation pathways, with the aim of accelerating the innovation and application of organoid biofabrication technology in China.更多还原