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Migrion:迁移体介导的细胞间病毒传播的新媒介(英文)

Migrion: a Migrasome-mediated unit for intercellular viral transmission

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【作者】 黄宇星晏晓杰刘杏吉聪聪田文敏汤号号黎勇文艺玲樊沛瑶王泓力郗灿坤李中天陆天游富平尹鑫陈扬

【Author】 Yuxing Huang;Xiaojie Yan;Xing Liu;Congcong Ji;Wenmin Tian;Haohao Tang;Yong Li;Yiling Wen;Peiyao Fan;Hongli Wang;Cankun Xi;Zhongtian Li;Tian Lu;Fuping You;Xin Yin;Yang Chen;Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Institute of Advanced Clinical Medicine, Peking University;Department of Obstetrics and Gynecology, Peking University First Hospital;State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences;Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital &Institute;Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, Peking University;Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Institute of Systems Biomedicine, Peking University Health Science Center;Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University;

【通讯作者】 游富平;尹鑫;陈扬;

【机构】 Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Institute of Advanced Clinical Medicine, Peking UniversityDepartment of Obstetrics and Gynecology, Peking University First HospitalState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural SciencesKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital &InstituteBeijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, Peking UniversityDepartment of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Institute of Systems Biomedicine, Peking University Health Science CenterDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University

【摘要】 <正>Viruses have evolved diverse strategies to propagate between cells. Classical paradigms describe two primary transmission modes:cell-free diffusion, where virions navigate extracellular spaces to initiate new infections, and direct cell-to-cell spread that minimizes exposure to host immunity [1,2]. In recent years, a third mechanism has emerged wherein viruses exploit extracellular vesicles (EVs) as intercellular transmission carriers.

【关键词】 intercellular英文immunityvesiclesinitiatediversepropagateexploitevolved病毒
【基金】 supported by the Ministry of Science and Technology of the People’s Republic of China (2022ZD0212900);the National Natural Science Foundation of China (32300570);the Beijing Natural Science Foundation (5244036);the National Key Research and Development Program of China (2023YFF0613402);the Clinical Medicine Plus X-Young Scholars Project of Peking University (PKU2025PKULCXQ013);the Research Funds from Health@Inno HK Program launched by Innovation Technology Commission of the Hong Kong Special Administrative Region
  • 【文献出处】 Science Bulletin ,科学通报(英文版) , 编辑部邮箱 ,2026年04期
  • 【分类号】Q939.4
  • 【下载频次】3
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