【摘要】 <正>Severe fever with thrombocytopenia syndrome virus(SFTSV) is an emerging bunyavirus that causes severe fever with thrombocytopenia syndrome(SFTS) [1] and is showing a trend toward global transmission [2]. Therefore, a comprehensive understanding of the pathogenic mechanism of SFTSV remains crucial.Apoptosis, a highly regulated process of programmed cell death,serves as a cellular immune response against invading pathogens[3]. In the intrinsic apoptosis pathway, the transduction of the apoptosis signal begins with damage to the mitochondrial membrane [4]. However, recent studies have shown a contradiction between SFTSV-induced mitochondrial damage and the inhibition of apoptosis [1,5,6], which emphasizes the importance of further exploring the regulatory mechanisms of SFTSV on apoptosis.更多还原