【摘要】 复发性流产（RSA）是育龄妇女常见的妊娠并发症，病因复杂。近年来，甲状腺自身免疫（TAI），特别是甲状腺过氧化物酶抗体（TPOAb）和甲状腺球蛋白抗体（TgAb），作为RSA的潜在危险因素受到广泛关注。文章基于近5年的研究进展，综述了TPOAb和TgAb与RSA相关的流行病学证据、潜在致病机制及临床管理策略。大量证据表明，即使在甲状腺功能正常的女性中，TPOAb/TgAb阳性也可能是RSA的独立危险因素，其机制可能与甲状腺功能潜在损伤、免疫紊乱、胎盘功能异常有关。因此，对RSA患者进行甲状腺自身抗体筛查并实施个体化管理，对改善妊娠结局具有重要意义。更多还原

【Abstract】 Recurrent spontaneous abortion(RSA) is a common pregnancy complication in women of reproductive age, with complex etiologies. In recent years, thyroid autoimmunity(TAI), particularly thyroid peroxidase antibody(TPOAb) and thyroglobulin antibody(TgAb), has attracted widespread attention as a potential risk factor for RSA. Based on research progress from the past five years, this article reviews epidemiological evidence, potential pathogenic mechanisms, and clinical management strategies related to TPOAb and TgAb in RSA. Substantial evidence suggests that even in women with normal thyroid function, TPOAb/TgAb positivity may be an independent risk factor for RSA. The underlying mechanisms may involve potential thyroid dysfunction, immune dysregulation, and abnormal placental function. Therefore, screening for thyroid autoantibodies in RSA patients and implementing individualized management are of significant importance for improving pregnancy outcomes.更多还原