【摘要】 目的 探讨生活用水硬度与银屑病患病风险之间的关联，为制定相关预防策略提供科学依据。方法 基于英国生物银行的基线数据，使用logistic回归分析模型探究生活用水硬度与银屑病患病风险的关联。同时，按性别、年龄、体质量指数分组开展亚组分析，并通过两项敏感性分析验证结果稳健性：一是排除任一变量存在信息缺失的参与者后重新分析，二是合并水硬度分类，再次评估其与银屑病患病风险的关联。结果 共纳入497 389名研究对象，生活用水硬度（以CaCO₃计算）每升高50 mg/L,银屑病患病风险降低（OR=0.935, 95%CI:0.926～0.943,P<0.001）。此外，生活用水硬度（CaCO₃>200 mg/L）与银屑病患病率呈负相关（OR=0.721, 95%CI:0.692～0.752,P<0.001）。亚组分析结果显示，男性（OR=0.944, 95%CI:0.932～0.956,P<0.001）、<60岁（OR=0.925, 95%CI:0.914～0.936,P<0.001）和体质量指数正常者（OR=0.932, 95%CI:0.916～0.948,P<0.001）中生活用水硬度与银屑病患病率呈负相关。敏感性分析结果与主要分析一致：排除信息缺失的参与者后，CaCO₃浓度每升高50 mg/L,银屑病患病风险降低（OR=0.933, 95%CI:0.924～0.941,P<0.001）;合并水硬度分类后，与≤60 mg/L组相比，>120 mg/L组银屑病患病风险同样降低（OR=0.764, 95%CI:0.731～0.799,P<0.001）。结论 生活用水硬度与银屑病患病风险之间存在负相关，男性、<60岁和体质量指数正常者为重点人群。更多还原

【Abstract】 Objective To explore the relationship between domestic water hardness and the risk of psoriasis, and providing a scientific basis for developing relevant preventive strategies. Methods Using baseline data from the UK Biobank, we used logistic regression analysis to examine the relationship between domestic water hardness and psoriasis prevalence. Stratified analyses were conducted by gender, age, and body mass index. Additionally, two sensitivity analyses were performed to assess the robustness of the findings: first, reanalyzing the data after excluding participants with missing information for any variable, and second, consolidating hard water categories to further evaluate their association with the risk of psoriasis prevalence. Results A total of 497 389 participants were included. For every 50 mg/L increase in water hardness（measured as CaCO₃）, the risk of psoriasis decreased（OR=0.935, 95% CI: 0.926-0.943, P<0.001）. Furthermore, exposure to domestic water hardness（CaCO₃> 200 mg/L） was negatively associated with psoriasis prevalence（OR=0.721, 95% CI: 0.692-0.752, P<0.001）. This protective association was more pronounced in males（OR=0.944, 95% CI: 0.932-0.956, P<0.001）, individuals under 60 years of age（OR=0.925, 95% CI: 0.914-0.936, P<0.001）, and those with normal body mass index（OR=0.932, 95% CI: 0.916-0.948, P<0.001）. The sensitivity analysis results were consistent with the primary findings: excluding participants with missing information, a 50 mg/L increase in CaCO₃ concentration was associated with a reduced risk of psoriasis（OR=0.933, 95% CI: 0.924-0.941, P<0.001）. Additionally, after consolidating hard water categories, the risk of psoriasis was significantly lower in the group with hardness >120 mg/L compared to the ≤60 mg/L group（OR=0.764, 95% CI: 0.731-0.799, P<0.001）. Conclusions There is a negative correlation between domestic water hardness and psoriasis prevalence. Men, under 60 years old, and those with a normal body mass index are the key populations.更多还原