【摘要】 紧密连接蛋白5(CLDN5)是细胞间紧密连接蛋白的关键结构成分，已被确定为血脑屏障中最重要的细胞间紧密连接蛋白之一。许多研究证明，血脑屏障功能障碍是抑郁症发生、发展的重要机制。作为血脑屏障中最重要的细胞间紧密连接蛋白之一的CLDN5也受到了广泛关注。现综述CLDN5基因与抑郁症的发生和治疗的研究，为未来研究提供参考。更多还原

【Abstract】 Claudin 5(CLDN5) is a key structural component of intercellular tight junction proteins and has been identified as one of the most important intercellular tight junction proteins in the blood-cerebrospinal fluid barrier. Numerous studies have demonstrated that blood-cerebrospinal fluid barrier dysfunction is an important mechanism in the occurrence and progression of depressive disorder. CLDN5, one of the most important intercellular tight junction proteins in the blood-cerebrospinal fluid barrier, has also received much attention. This paper reviews the relationship between CLDN5 gene and the occurrence and treatment of depressive disorder, aiming to provide a reference for future research.更多还原