【摘要】 苏木作为一种重要的传统药用植物,其药理活性在多个治疗领域得到广泛应用与实证研究。巴西木素被确认为苏木的关键药效物质基础及特征性化学标志物,该分子在多种体外和体内模型中展现出抗肿瘤、抗炎、抗血小板聚集、调节血糖代谢、广谱抗菌及肝脏保护作用等多靶点生物活性。巴西木素分子因其显著的生物活性及结构复杂性,成为药物化学和天然产物全合成领域的研究热点。本综述系统性地梳理与评述了2015年以来巴西木素及其类似物的合成研究进展,并对该类化合物未来的发展趋势进行了展望。更多还原

【Abstract】 Sappan wood serves as an important traditional medicinal herb,with its pharmacological activities extensively applied and empirically validated across multiple therapeutic areas.Brazilin is identified as the key active component and characteristic chemical marker of sappan wood.This molecule demonstrates a multi-target bioactivity profile in various in vitro and in vivo models,encompassing anti-tumor,anti-inflammatory,anti-platelet aggregation,blood glucose metabolism regulation,broad-spectrum antibacterial,and hepatoprotective effects.Owing to its significant biological activities and structural complexity,brazilin has become a research hotspot in the fields of medicinal chemistry and natural product total synthesis.The research progress in the synthesis of brazilin and its analogs since 2015 were systematically summarized and discussed in this review,while also providing perspectives on future development trends of these compounds.更多还原