【摘要】 目的:观察自拟脉通凝汤联合腔内介入治疗下肢深静脉血栓(deep vein of lower extremities,DVT)的疗效。方法:选取2023年1月至2024年12月漯河市中医院收治的DVT患者88例为研究对象，随机分为对照组和观察组，每组各44例。对照组采用腔内介入治疗，观察组在对照组治疗的基础上采用自拟脉通凝汤治疗，观察两组患者临床疗效、中医证候积分、凝血功能、下肢血液循环情况、炎症因子水平、药物安全性。结果:观察组有效率高于对照组，差异有统计学意义(P<0.05);观察组中医证候积分包括下肢肿胀积分、皮肤发红积分、胀痛发热积分、舌红苔黄积分均低于对照组，差异有统计学意义(P<0.05);观察组活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶时间(thrombin time,TT)、凝血酶原时间(prothrombin time,PT)高于对照组，而D-二聚体(d-dimer,D-D)水平低于对照组，差异有统计学意义(P<0.05);观察组下肢血液循环指标踝肱指数(ankle brachial index,ABI)高于对照组，搏动指数(pulsatility index,PI)、阻力指数(resistive index,RI)均小于对照组，差异有统计学意义(P<0.05);观察组白细胞介素-8(interleukin-8,IL-8)、肿瘤坏死因子α(tumour necrosis factor-α,TNF-α)、C反应蛋白(C-reactive protein,CRP)水平均低于对照组(P<0.05);两组患者不良反应发生率比较，差异无统计学意义(P > 0.05)。结论:自拟脉通凝汤联合腔内介入治疗DVT具有较好疗效，可缓解患者症状，改善血液循环，降低炎症因子水平。更多还原

【Abstract】 Objective: To observe the efficacy of the Self-formulated Maitongning Decoction combined with endovascular intervention on deep vein thrombosis( DVT) of the lower extremities. Methods: A total of 88 DVT patients admitted to Luohe Hospital of Traditional Chinese Medicine from January 2023 to December 2024 were selected as the study subjects and randomly divided into the control group and the observation group,with 44 cases in each group. The control group was treated with endovascular intervention,while the observation group was treated with the Self-formulated Maitongning Decoction in addition to the treatment given to the control group. The clinical efficacy,TCM syndrome scores,coagulation function,lower limb blood circulation,inflammatory factors,and treatment safety were observed in the two groups. Results: The effective rate in the observation group was higher than that in the control group,and the difference was statistically significant( P < 0. 05). The TCM syndrome scores in the observation group,including lower limb swelling,skin redness,distending pain and fever,and red tongue with yellow coating,were lower than those in the control group,with statistically significant differences( P < 0. 05). The activated partial thromboplastin time( APTT),thrombin time( TT),and prothrombin time( PT) in the observation group were higher than those in the control group,while the D-dimer( D-D) level was lower than that in the control group,with statistically significant differences( P < 0. 05). Regarding lower limb blood circulation indicators,the ankle-brachial index( ABI) in the observation group was higher than that in the control group,while the pulsatility index( PI) and resistive index( RI)were both lower than those in the control group,with statistically significant differences( P < 0. 05). The levels of interleukin-8( IL-8),tumor necrosis factor-α( TNF-α),and C-reactive protein( CRP) in the observation group were all lower than those in the control group( P < 0. 05). However,there was no statistically significant difference in the incidence of adverse reactions between the two groups( P >0. 05). Conclusion: The self-formulated Maitongning Decoction combined with endovascular intervention has a good therapeutic effect on DVT. It can alleviate patients’ symptoms,improve their blood circulation speed,and reduce the levels of inflammatory factors.更多还原