【摘要】 目的 探究并分析超声心动图与脑钠肽(BNP)、肌酸激酶同工酶(CK-MB)、肌红蛋白(Myo)对急性心肌梗死的诊断价值。方法 纳入2021年11月至2023年10月河南省中医院收治的急性心肌梗死患者共98例作为观察组，另选择同期河南省中医院门诊健康体检者80例作为对照组，所有研究对象均进行超声心动图检查、CK-MB、Myo和BNP检测，并比较两组研究对象CK-MB、Myo和BNP水平、心功能指标变化以及联合诊断效能。结果 血清学检测结果显示，观察组CK-MB、Myo和BNP水平均较对照组更高，差异有统计学意义(P<0.05);超声心动图相关心功能检测指标结果显示，与对照组相比，观察组左室舒张末内径(LVEDD)和左室收缩末内径(LVESD)水平提高，左室射血分数(LVEF)则下降(P<0.05);经受试者工作特征(ROC)曲线分析显示，四项联合检验(超声心动图、BNP、CK-MB和Myo)的敏感度为95.90%,曲线下面积(AUC)值为0.984,高于四项单独检测的敏感度与AUC值(P<0.05)。结论 经检测，BNP、CK-MB和Myo在急性心肌梗死诊断中异常高表达，与超声心动图联合检测，可提高诊断效能，具有重要临床意义。更多还原

【Abstract】 Objective To explore and analyze the diagnostic value of echocardiography combined with brain natriuretic peptide(BNP), creatine kinase isoenzyme-MB(CK-MB) and myoglobin(Myo) in acute myocardial infarction. Methods A total of 98 patients with acute myocardial infarction admitted to Henan Hospital of Traditional Chinese Medicine from November 2021 to October 2023 were included as the observation group. In addition, 80 healthy individuals who underwent outpatient physical examinations in Henan Hospital of Traditional Chinese Medicine were selected as the control group. All study subjects underwent echocardiography, CK-MB, Myo, BNP detection, and CK-MB, Myo, BNP levels, changes in cardiac function indicators, and combined diagnostic efficacy were compared between the two groups. Results The serological test results were showed that the observation group levels of CK-MB, Myo and BNP were both higher than those of the control group, with significant differences(P<0.05). The results of functional testing indicators related to echocardiography were showed that compared with the control group, the observation group had higher levels of left ventricular end-diastolic diameter(LVEDD) and left ventricular end systolic diameter(LVESD), but left ventricular ejection fraction(LVEF) decreased(P<0.05). According to receiver operating characteristic(ROC) curve analysis, four joint tests(the sensitivity of echocardiography, BNP, CK-MB, and Myo was 95.90%, the area under the curve(AUC) value was 0.984, which was higher than the sensitivity and AUC value of the four individual tests(P<0.05). Conclusion After testing, BNP, CK-MB and Myo are abnormally highly expressed in the diagnosis of acute myocardial infarction. Combined detection with echocardiography can improve diagnostic efficiency and has important clinical significance.更多还原