【摘要】 目的 探究纤维蛋白降解产物与纤维蛋白原比值(FDP/FIB)、D-二聚体(D-D)及C反应蛋白(CRP)水平在急诊严重创伤患者预后评估中的应用价值。方法 回顾性选取2021年7月至2024年1月平顶山市第一人民医院收治的113例急诊严重创伤患者为研究对象，对接受治疗后转入ICU的患者进行为期28 d的观察，根据患者治疗最终结局分为存活91例(预后良好组)，非存活22例(预后不良组)。比两组患者治疗后FDP/FIB、D-D及CRP表达水平。logistic回归分析急诊严重创伤患者预后的影响因素，受试者工作特征(ROC)曲线分析FDP/FIB、D-D及CRP水平对急诊严重创伤患者预后的预测价值。结果 预后不良组患者FDP/FIB、D-D和CRP表达水平均高于良好组(P<0.05);两组患者年龄、性别、住院时间、受伤部位(腹部或腰椎、四肢或盆骨)和致伤原因等方面差异无统计学意义(P >0.05);预后不良组患者头颈损伤(90.91%)、胸部或腰椎损伤(95.45%)均高于预后良好组(P<0.05);经logistic回归分析，FDP/FIB、D-D、CRP水平均为影响急诊严重创伤患者预后不良的独立危险因素(P<0.05);经ROC曲线分析，FDP/FIB、D-D、CRP水平均对急诊严重创伤患者预后不良均有较高的预测价值，曲线下面积(AUC)值分别为0.919、0.833、0.905。结论 FDP/FIB、D-D和CRP水平情况与急诊严重创伤患者的预后情况密切相关，对其进行检测有助于评估患者预后情况。更多还原

【Abstract】 Objective To explore the application value of fibrinogen degradation product/fibrinogen( FDP/FIB),D-dimer( D-D),and C-reactive protein( CRP) levels in the prognosis evaluation of emergency severe trauma patients. Methods A total of 113 critically injured emergency patients admitted to the First People’s Hospital of Pingdingshan City from July 2021 to January 2024 as the study subjects were selected retrospectively. Patients who were transferred to the ICU after receiving treatment were observed for 28 days. According to the final treatment outcome,91 patients survived( good group) and 22 patients did not survive( poor group). The expression levels of FDP/FIB,D-D,and CRP between the two groups of patients after treatment were compared. Logistic regression analysis was used to identify the influencing factors on the prognosis of critically injured emergency patients,while receiver operating characteristic( ROC) curve analysis was used to assess the predictive value of FDP/FIB,D-D levels,and CRP expression on the prognosis of critically injured emergency patients.Results The expression levels of FDP/FIB,D-D,and CRP in patients with poor prognosis were higher than those in the good group( P < 0. 05). There was no statistically significant difference in terms of age,gender,length of hospital stay,location of injury( abdomen or lumbar spine,limbs or pelvis),and cause of injury between the two groups of patients( P > 0. 05). The head and neck injuries( 90. 91%) and chest or lumbar spine injuries( 95. 45%) in the poor prognosis group were higher than those in the good prognosis group( P < 0. 05). Through logistic regression analysis,the expression levels of FDP/FIB,D-D,and CRP were all independent risk factors for poor prognosis in emergency severely injured patients( P < 0. 05),and they were all positively correlated. According to ROC curve analysis,the expression levels of FDP/FIB,D-D,and CRP had high predictive value for poor prognosis in emergency severely injured patients,with area under the curve( AUC) values of 0. 919,0. 833,and 0. 905,respectively. Conclusion FDP/FIB,D-D and CRP levels are closely related to the prognosis of emergency patients with severe trauma,and testing them can help to evaluate the patient prognosis.更多还原