【摘要】 自组装纳米粒(self-assembled nanoparticles,SANs)是一类通过分子间非共价相互作用自发形成的纳米尺度组装体。SANs可影响其活性成分的吸收及分布，且在生物活性方面优于游离活性成分或其简单混合物。通过纳米沉淀法、乳化-溶剂挥发法、溶剂热法等方法可构建天然药物SANs，其理化性质及药物释放等性能均优于原药物。然而，SANs的稳定性及工业化应用还有待进一步研究。基于SANs的优异性能，其有望成为下一代精准药物递送系统的重要载体，为重大疾病的治疗提供新策略。更多还原

【Abstract】 Self-assembled nanoparticles(SANs) are a class of nanoscale assemblies that spontaneously form through intermolecular non-covalent interactions. SANs can influence the absorption and distribution of their active components and often exhibit superior activity compared with free active compounds or their simple mixtures. Natural productbased SANs can be constructed using methods such as nanoprecipitation, emulsion-solvent evaporation, and solvothermal techniques, and their physicochemical properties and drug release performance are generally superior to those of the parent compounds. However, the stability and large-scale industrial application of SANs still require further investigation. Owing to their advantageous properties, SANs are expected to become important carriers in next-generation precision drug delivery systems, providing new strategies for the treatment of major diseases.更多还原