【摘要】 总结115例难治/复发B细胞非霍奇金淋巴瘤患者接受BEAM或BEAMF预处理方案自体造血干细胞移植序贯CD19/22嵌合抗原受体T细胞治疗的护理经验。BEAM组和BEAMF组成功植入中性粒细胞的中位时间和血小板植入的中位时间均为14 d和15 d。患者均因清髓性预处理方案而出现3级或4级血细胞减少症，毒性反应主要为口腔黏膜炎、低血压、肝功能异常和发热等。护理要点包括护理人员掌握毒性反应的叠加效应，能预见BEAMF预处理方案可能导致的风险，落实各项护理措施以保障患者治疗安全。更多还原

【Abstract】 We summarize the nursing experience for 115 patients with refractory or relapsed B cell non-Hodgkin lymphoma who underwent autologous hematopoietic stem cell transplantation(auto HSCT) conditioned with either BEAM or BEAMF followed by sequential CD19/22 chimeric antigen receptor T cell(CAR-T) therapy. In both the BEAM and BEAMF groups, the median time to neutrophil engraftment was 14 days and the median time to platelet engraftment was 15 days. All patients experienced grade 3-4 cytopenias attributable to the myeloablative conditioning regimens. The primary toxicities observed were oral mucositis, hypotension, abnormal liver function, and fever. Key nursing considerations included awareness of cumulative toxicities from sequential treatments, anticipation of risks specifically associated with the BEAMF conditioning regimen, and rigorous implementation of targeted nursing interventions to ensure treatment safety.更多还原