【摘要】 目的 探讨精准营养干预在腹腔镜胃癌手术患者中的应用效果。方法 选取2023年1月—2024年2月医院接受腹腔镜手术治疗的胃癌患者162例为研究对象，将患者按照组间资料具有可比性的原则分为观察组和对照组，每组81例。观察组实施精准营养干预，对照组常规营养管理。对比两组患者术后体质量、上臂肌围（AMC）、手握力、术后恢复情况、血清白蛋白（ALB）、前白蛋白（PA）、血红蛋白（Hb）、转铁蛋白（TRF）、血清补体C3、血清补体C4、C反应蛋白（CRP）、不良反应及并发症发生情况。结果 干预7 d后，观察组患者体质量、AMC和手握力情况均优于对照组，差异有统计学意义（P<0.05）。干预7 d后，观察组患者血液营养指标（ALB、Hb、PA、TRF）均高于对照组，差异有统计学意义（P<0.05）。干预7 d后，观察组患者血清补体C3、CRP均低于对照组，差异有统计学意义（P<0.05）。干预后，观察组患者首次肛门排气时间、首次下床时间、恢复全流质饮食时间、恢复半流质饮食时间、引流管拔除时间及术后住院时间较对照组短，差异有统计学意义（P<0.05）。两组患者术后均无死亡病例，无胃瘫等严重并发症。观察组患者术后不良反应总发生率低于对照组，差异有统计学意义（P<0.05）。结论 对腹腔镜胃癌手术患者实施精准营养干预能改善其营养状况，降低胃肠道反应及术后并发症发生率，减轻应激反应，促进术后康复。更多还原

【Abstract】 Objective To investigate the efficacy of precision nutrition intervention in patients underwent laparoscopic gastrectomy operation of gastric cancer. Methods A total of 162 patients underwent laparoscopic surgery for gastric cancer from January 2023 to February 2024 were enrolled. Participants were allocated to an observation group and a control group based on comparable baseline characteristics, with 81 cases in each group. The observation group received precision nutrition intervention, the control group underwent conventional nutritional management. Postoperative body weight, upper arm circumference(UAC), handgrip strength, postoperation recovery status, serum albumin(ALB), prealbumin(PA), haemoglobin(Hb), transferrin(TRF), serum complement C3, serum complement C4, C-reactive protein(CRP), adverse events, and complications were compared between groups. Results After 7 d of intervention, patients in the observation group demonstrated superior body weight, AMC, and handgrip strength compared to the control group, with statistically significant diff erences(P<0.05). After 7 d of intervention, blood nutritional indicators(ALB, Hb, PA, TRF) were higher in the observation group than in the control group, with statistically significant diff erences(P<0.05). After 7 d of intervention, serum complement C3 and CRP levels in the observation group were lower than those in the control group, with statistically significant differences(P<0.05). After intervention, patients in the observation group demonstrated shorter times to first anal flatus, first ambulation, resumption of full liquid diet, resumption of semi-liquid diet, removal of drainage tubes, and postoperative hospital stay compared to the control group, with statistically significant differences(P<0.05). There were none postoperative deaths or severe complications such as gastric paralysis occurred in either group. The overall incidence of adverse reactions was lower in the observation group than in the control group, with statistically significant diff erences(P<0.05). Conclusion Implementing precision nutritional intervention in patients undergoing laparoscopic gastric cancer surgery improves nutritional status, reduces the incidence of gastrointestinal reactions and postoperative complications, alleviates stress responses, and promotes postoperative recovery.更多还原