【摘要】 光热治疗(PTT)通过光热剂(PTAs)吸收近红外光,将光激发产生的非辐射能量耗散到病灶部位,实现局部组织的热消融,为治疗肿瘤及细菌感染提供了新途径,但开发兼具高效光热转换与精准靶向功能的有机PTAs面临挑战。本文聚焦七甲川花菁(Cy7)染料分子工程优化,提出聚集态调控与功能基团协同强化策略,在中性Cy7骨架上引入三苯基磷阳离子(TPP~+),构建新型阳离子衍生物Cy7T-TPP。该衍生物具有三重优势:TPP~+赋予细菌膜锚定与线粒体靶向能力;诱导H-聚集体增强分子间紧密堆叠,光热转换效率达到51.65%;TPP~+屏蔽活性氧攻击,提升稳定性。实验证实Cy7T-TPP的抗肿瘤及抗菌效能优异,为高稳定、靶向性有机光热材料的开发提供了分子工程新范式。更多还原

【Abstract】 Photothermal therapy(PTT) provides a new approach for the treatment of tumors and bacterial infections.It relies on photothermal agents(PTAs) to absorb near-infrared light,dissipate the non-radiative energy generated by photoexcitation to the lesion site,and achieve thermal ablation of local tissues.However,the development of organic PTAs with both efficient photothermal conversion and precise targeting functions is challenging.This paper focuses on the molecular engineering optimization of heptamethine cyanine(Cy7) dye molecules,and proposes a strategy of aggregate state regulation and synergistic enhancement of functional groups.A novel cationic derivative Cy7T-TPP is constructed by introducing triphenylphosphine cation(TPP~+) into the neutral cyanine skeleton.This derivative has three advantages:TPP~+ endows it with bacterial membrane anchoring and mitochondrial targeting capabilities;it induces H-aggregates to enhance the close stacking between molecules,with a photothermal conversion efficiency of 51.65%;TPP~+ shields against reactive oxygen species attack and improves stability.Experiments have confirmed that Cy7T-TPP has excellent anti-tumor and antibacterial efficacy,providing a new molecular engineering paradigm for the development of highly stable and targeted organic photothermal materials.更多还原