【摘要】 N6-甲基腺嘌呤（N6-methyladenosine,m6A）是真核生物RNA上一种常见的化学修饰,m6A甲基化修饰可以调控RNA前体的剪切、RNA核输出、翻译过程以及影响RNA稳定性,不仅对细胞内基因的表达具有重要影响,还参与基因表达的调控,进而对多种生物体的基因表达产生深远的影响。此外,细胞自噬是真核生物中进化保守的对细胞内物质进行周转的重要过程,有助于维持细胞正常的新陈代谢。本文就m6A甲基化修饰在细颗粒物(fine particulate matter,PM_2.5)诱导的肺损伤发生发展过程中对细胞自噬调控作用的研究进展作一综述,旨在为今后研究m6A修饰调控细胞自噬在PM_2.5诱导的肺损伤中的作用提供参考,为PM_2.5诱导肺损伤治疗提供新的方向。更多还原

【Abstract】 N6-methyladenosine（m6A） is a common chemical modification on eukaryotic RNA. The m6A methylation modification can regulate the splicing of RNA precursors,RNA nuclear export,translation process,and affect RNA stability. It not only has a significant influence on the expression of genes within cells but also participates in the regulation of gene expression,thereby exerting a profound influence on the gene expression of various organisms. In addition,autophagy is an evolutionarily conserved process in eukaryotes for the turnover of intracellular substances,which helps maintain normal cellular metabolism. This article summarized the research progress on the regulation of autophagy by m6A modification during the occurrence and development of fine particulate matter(PM_2.5)-induced lung injury,aiming to provide a reference for future studies on the regulatory mechanism of m6A modification in regulating autophagy levels in PM_2.5-induced lung injury and present a new direction for the exploration of treatment strategies for PM_2.5-induced lung injury.更多还原