【摘要】 伤口愈合目前面临诸多问题，且并发症较多，严重威胁全身健康。当前，使用新型敷料水凝胶代替传统敷料治疗，较好解决了传统敷料的劣势，但仍存在无法精准抵达靶位点、释放难以控制、易引发全身副作用等问题。智能响应型水凝胶感应灵敏，可通过自身理化性质做出响应，快速可针对性释放药物治疗各种伤口。因此，综述了水凝胶在伤口愈合中的研究现状，重点探讨了智能响应型水凝胶(如pH响应型、酶响应型、光响应型和糖响应型)的构建方法以及在伤口愈合中的应用，并分析智能响应型水凝胶载药系统当前面临的挑战，如药物释放速度的调控、生物相容性与降解性的平衡、机械性能与稳定性的优化等。最后，展望了智能响应型水凝胶的未来发展方向，提出通过微流控、新型材料交联等先进技术优化药物释放调控，开发多功能复合水凝胶，以进一步提升其在伤口愈合中的应用效果并发挥更优秀的临床价值。更多还原

【Abstract】 Wound healing currently faces numerous challenges and is accompanied by many complications, which pose a serious threat to overall health.At present, the use of novel hydrogel dressing as alternatives to traditional dressings has effectively addressed the shortcomings of traditional dressings.However, issues such as the inability to accurately target wound sites, difficult-to-control drug release, and the potential to induce systemic side effects still exist.Smart-responsive hydrogels are highly sensitive and can respond through their intrinsic physical and chemical properties, enabling rapid target drug release for the treatment of various wounds.Therefore, this review summarized the research status of hydrogels in wound healing, focusing on the construction methods of smart-responsive hydrogels(e.g.,pH-responsive, enzyme-responsive, light-responsive, and glucose-responsive types) and their applications in wound healing.It also analyzed the current challenges faced by smart-responsive hydrogel drug delivery systems, such as the regulation of drug release rate, the balance between biocompatibility and degradability, and the optimization of mechanical properties and stability.Finally, it looked forward to the future development directions of smart-responsive hydrogels, and proposed to optimize the regulation of drug release through advanced technologies such as microfluidics and novel material cross-linking, as well as to develop multifunctional composite hydrogels, aiming to further improve their application effects in wound healing and exert better clinical value.更多还原