【摘要】 乙苯选择性氧化制备苯乙酮（OEB-AP）是精细化工中合成高附加值含氧化合物的重要反应。OEB-AP绿色、经济的特性使其成为传统Friedel-Crafts酰基化和Hock工艺的理想替代方案。然而，该反应面临C—H键活化困难、转化率与选择性低等问题，亟需开发高效催化剂。钴基催化剂因多价态特性(Co²⁺/Co³⁺)和优异的氧化还原性能，在OEB-AP反应中展现出显著优势。本文系统综述了多相钴基催化剂的研究进展，多相体系通过载体设计（如SiO₂、CeO₂、碳材料）和结构调控（单原子、MOF衍生催化剂）优化性能，其中CeO₂载体的氧空位与钴物种的协同作用、碳基材料的杂原子掺杂（N/S）及MOF衍生Co-N-C催化剂表现突出。未来研究需聚焦于抑制苯甲酸副产物、降低反应条件苛刻性，并探索钴活性中心与载体相互作用的机制，以实现工业化应用。更多还原

【Abstract】 The selective oxidation of ethylbenzene to acetophenone（OEB-AP） is a pivotal reaction in the fine chemical industry for synthesizing high-value-added oxygenated compounds. Its green and economical profile makes it an ideal alternative to traditional Friedel-Crafts acylation and the Hock process. However,this reaction faces challenges such as difficult C—H bond activation,low conversion and selectivity,necessitating the development of highly efficient catalysts. Cobalt-based catalysts,leveraging their multivalent nature(Co^{2 +}/Co³⁺) and exceptional redox properties,have demonstrated significant advantages in the OEB-AP reaction. This article provides a systematic review of recent advances in heterogeneous cobalt-based catalysts for this reaction. In contrast,heterogeneous systems have achieved optimized performance through carrier design（e. g.,SiO₂,CeO₂,carbon materials） and structural modulation（e. g.,single-atom catalysts and MOF-derived catalysts）. Among these,the synergistic effect between oxygen vacancies in CeO₂ carriers and cobalt species,heteroatom doping（N/S） in carbon-based materials,and MOF-derived Co-N-C catalysts have shown particularly promising performance. Future research should focus on suppressing benzoic acid byproduct formation,reducing the severity of reaction conditions,and elucidating the interaction mechanisms between cobalt active centers and carriers to facilitate industrial application.更多还原